Results 121 to 130 of about 3,675 (154)

Pharmacogenetic Profiling of Genes Associated with Outcomes of Chemotherapy in Omani Healthy Controls. [PDF]

Genes (Basel)
Al-Mahrouqi N, Al Shuaili N, Al-Zadjali S, Pullanhi A, Al-Barwani H, Al-Kindy A, Al-Sharqi H, Al-Baimani K, Al-Moundhri M, Salman B.   +9 more
europepmc   +1 more source

ABCC4 is regulated by microRNA-124a and microRNA-506 [PDF]

Biochemical Pharmacology, 2014
Multidrug resistance protein 4 (MRP4, ABCC4) is an efflux membrane transporter expressed in renal tubules, hepatocytes, brain capillaries, prostate and blood cells. MRP4 drives energy dependent efflux of important physiological and pharmacological compounds.
Deanna L. Kroetz
exaly   +5 more sources

Implications of ABCC4–Mediated cAMP Efflux for CRC Migration [PDF]

Cancers, 2020
Colorectal cancer (CRC) presents significant molecular heterogeneity. The cellular plasticity of epithelial to mesenchymal transition (EMT) is one of the key factors responsible for the heterogeneous nature of metastatic CRC. EMT is an important regulator of ATP binding cassette (ABC) protein expression; these proteins are the active transporters of a ...
Izabela Papiewska-Pająk, Joanna Boncela, Jakub Kryczka   +2 more
exaly   +3 more sources

Drug resistance biomarker ABCC4 of selinexor and immune feature in multiple myeloma

International Immunopharmacology, 2022
The treatment of relapse or refractory multiple myeloma (RRMM) is still a big challenge in clinic. Recently, several clinical trials indicated that the XPO1 inhibitor, selinexor could significantly improve the remission rate in MM patients. However, the heterogeneous genetic background greatly influenced the efficiency of selinexor among MM.
Da-Wei Wang, Si-Liang Chen, Yang Liang
exaly   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

Dynamic Changes in ABCC4 Protein‐Protein Interactions during PKA Signaling: Role of the ABCC4 PDZ Motif

The FASEB Journal, 2022
We recently demonstrated that a protein interaction between the PDZ motif of ABCC4 and a single PDZ‐domain‐containing protein, MPP1 had an important role in ABCC4 function in acute myeloid leukemia (Pitre et al. Nature Comm . 2017).
Sabina Ranjit, Jingwen Zhu, Aaron Pitre, Yao Wang, Rebecca Crawford, Amanda Nourse, Yuxin Li, Vishwajeeth Pagala, Junmin Peng, John D. Schuetz   +9 more
openaire   +1 more source

Generation of Knockout and Transgenic Zebrafish to Characterize Abcc4 Functions in Detoxification and Efflux of Lead [PDF]

International Journal of Molecular Sciences, 2021
Lead (Pb) is one of the major heavy metals that are toxic to vertebrates and usually considered as environmental pollutants. ABCC4/MRP4 is an organic anion transporter that mediates cellular efflux of a wide range of exogenous and endogenous compounds such as cyclic nucleotides and anti-cancer drugs; however, it remains unclear whether ABCC4 and its ...
Yong Long, Hua Wen, Xing Lu
exaly   +3 more sources

The Abcc4 Knockout Reveals An Important Role for Abcc4 in Platelet Aggregation

Blood, 2011
Abstract Abstract 1141 Cyclic nucleotides have an important role in platelet aggregation and the role of phosphodiesterases in regulating their concentration is well known. Currently it is unknown if plasma membrane cyclic nucleotide export proteins regulate cyclic nucleotide concentrations in platelets.
Satish Babu Cheepala, Kazumasa Takenaka, Tamara I. Pestina, Carl W. Jackson, Schuetz John   +4 more
openaire   +1 more source

Oral Availability of Cefadroxil Depends on ABCC3 and ABCC4

Drug Metabolism and Disposition, 2012
Some cephalosporins, such as cefadroxil, are orally available. H(+)-coupled peptide transporter 1 mediates the transport of cephalosporins across the apical membrane of enterocytes. It is not known which mechanism(s) is responsible for the subsequent transport of cephalosporins across the basolateral membrane toward the circulation.
de Waart, Dirk R., van de Wetering, Koen, Kunne, Cindy, Duijst, Suzanne, Paulusma, Coen C., Oude Elferink, Ronald P. J.   +5 more
openaire   +2 more sources

Structural insights into human ABCC4-mediated transport of platelet agonist and antagonist

Nature Cardiovascular Research, 2023
Human platelets contribute to hemostasis and thrombosis, the imbalance of which can cause cardiovascular diseases. The activation and accumulation of platelets can be induced by agonists or inhibited by antagonists. Thus, the human ABC transporter ABCC4, which pumps out platelet agonists and antagonists, might become a promising target for preventing ...
Yu Chen, Liang Wang, Wen-Tao Hou, Zhihui Zha, Kang Xu, Cong-Zhao Zhou, Qiong Li, Yuxing Chen   +7 more
openaire   +2 more sources