Results 131 to 140 of about 3,675 (154)
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Unimpaired immune functions in the absence of Mrp4 (Abcc4)
Immunology Letters, 2009Dendritic cell (DC) migration to draining lymph nodes is important for the initiation of an effective immune response. Recently we reported that the human ATP-binding cassette (ABC) transporter multidrug resistance protein 4 (MRP4 and ABCC4) is required for the migration of human DC. Since the ABC transporter MRP1 (ABCC1) was previously shown to play a
van de Ven, R. +8 more
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The ABCC4 gene is a promising target for pancreatic cancer therapy
Gene, 2012Pancreatic cancer is a malignant neoplasm of the pancreas that usually has a poor prognosis. The investigation of targets that effectively inhibit pancreatic cancer cell proliferation should provide a fundamental basis for the clinical application of gene therapy.
Zhuo, Zhang +4 more
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Involvement of MRP4 (ABCC4) in the Luminal Efflux of Ceftizoxime and Cefazolin in the Kidney
Molecular Pharmacology, 2007The purpose of the present study was to investigate the role of multidrug resistance-associated protein 4 (MRP4) in the tubular secretion of cephalosporin antibiotics. Most of the injectable cephalosporins have an inhibitory effect on the ATP-dependent uptake of [(3)H]dehydroepiandrosterone sulfate by membrane vesicles expressing hMRP4, whereas ...
Lei, Ci +5 more
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Insights into platelet pharmacology from a cryo-EM structure of the ABCC4 transporter
Nature Cardiovascular Research, 2023Structural determination of the ABCC4 transporter is a major first step in providing crucial molecular insights into the transport of platelet substrates into granules, as well as drug transport from platelets. The findings provide a framework for understanding platelet interactions and potential design of specific platelet antagonists.
Anish V. Sharda, Sean X. Gu, John Hwa
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Multidrug resistance protein 4 (MRP4/ABCC4)
Trends in Pharmacological Sciences, 2008Multidrug resistance protein (MRP) 4 is a member of the MRP/ABCC subfamily of ATP-binding cassette transporters, which are capable of pumping a wide variety of endogenous and xenobiotic organic anionic compounds out of the cell. In addition to its role in the body distribution and renal excretion of a wide variety of antiviral, cytostatic, antibiotic ...
Russel, Frans G M +2 more
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The role of ABCC4 in pigment granule migration in RPE of mice
The FASEB Journal, 2022ABCC4 is an ATP‐binding cassette protein that exports many substrates, including cyclic adenosine monophosphate (cAMP). In mammals, cyclic AMP accumulates in retinal photoreceptors in dark conditions. We conjecture that cyclic AMP is exported from the photoreceptors into the sub‐retinal space, where it becomes available for uptake ...
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Archives of Dermatological Research, 2011
Xenobiotic transporters of the ATP-binding cassette (ABC) protein superfamily play important roles in maintaining the biochemical barrier of various tissues, but their precise functions in the skin are not yet known. Screening of the expressions of the known xenobiotic transporter genes in two in vitro keratinocyte differentiation models revealed that ...
Attila, Bebes +8 more
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Xenobiotic transporters of the ATP-binding cassette (ABC) protein superfamily play important roles in maintaining the biochemical barrier of various tissues, but their precise functions in the skin are not yet known. Screening of the expressions of the known xenobiotic transporter genes in two in vitro keratinocyte differentiation models revealed that ...
Attila, Bebes +8 more
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C-MYC Correlates with Expression of Multidrug Transporters ABCC1 and ABCC4.
Blood, 2007Abstract C-MYC is an oncogene with protean effects and there is some speculation that aberrant overexpression in cancer may be associated with drug resistance by increased expression of the Multi-Drug Resistance Transporters, for example ABCC4 (MRP4) and ABCC1 (MRP1).
Lye Lin Ho +7 more
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ABCB1 and ABCC4 efflux transporters are involved in methyl parathion detoxification in ZFL cells
Toxicology in Vitro, 2015The multi-xenobiotics resistance (MXR) mechanisms are the first line of defense against toxic substances in aquatic organisms and present great importance in the adaptation related to contaminated environments. Methyl parathion (MP) is a widely used organophosphate pesticide, which has been associated to various toxic effects in organisms.
Bruna Félix, Nornberg +4 more
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ABCC4 Impacts Megakaryopoiesis by Regulating Intracellular cAMP levels
The Journal of Pharmacology and Experimental Therapeutics, 2023Sabina Ranjit +7 more
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