Results 131 to 140 of about 3,461 (145)

FOXM1 induces therapy resistance and inhibits apoptosis in a variety of human cancers. [PDF]

Cell Death Dis
Raghuwanshi S, Gartel AL.
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Dynamic Changes in ABCC4 Protein‐Protein Interactions during PKA Signaling: Role of the ABCC4 PDZ Motif

The FASEB Journal, 2022
We recently demonstrated that a protein interaction between the PDZ motif of ABCC4 and a single PDZ‐domain‐containing protein, MPP1 had an important role in ABCC4 function in acute myeloid leukemia (Pitre et al. Nature Comm . 2017).
Sabina Ranjit, Jingwen Zhu, Aaron Pitre, Yao Wang, Rebecca Crawford, Amanda Nourse, Yuxin Li, Vishwajeeth Pagala, Junmin Peng, John D. Schuetz   +9 more
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The Abcc4 Knockout Reveals An Important Role for Abcc4 in Platelet Aggregation

Blood, 2011
Abstract Abstract 1141 Cyclic nucleotides have an important role in platelet aggregation and the role of phosphodiesterases in regulating their concentration is well known. Currently it is unknown if plasma membrane cyclic nucleotide export proteins regulate cyclic nucleotide concentrations in platelets.
Satish Babu Cheepala, Kazumasa Takenaka, Tamara I. Pestina, Carl W. Jackson, Schuetz John   +4 more
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Oral Availability of Cefadroxil Depends on ABCC3 and ABCC4

Drug Metabolism and Disposition, 2012
Some cephalosporins, such as cefadroxil, are orally available. H(+)-coupled peptide transporter 1 mediates the transport of cephalosporins across the apical membrane of enterocytes. It is not known which mechanism(s) is responsible for the subsequent transport of cephalosporins across the basolateral membrane toward the circulation.
de Waart, Dirk R., van de Wetering, Koen, Kunne, Cindy, Duijst, Suzanne, Paulusma, Coen C., Oude Elferink, Ronald P. J.   +5 more
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Unimpaired immune functions in the absence of Mrp4 (Abcc4)

Immunology Letters, 2009
Dendritic cell (DC) migration to draining lymph nodes is important for the initiation of an effective immune response. Recently we reported that the human ATP-binding cassette (ABC) transporter multidrug resistance protein 4 (MRP4 and ABCC4) is required for the migration of human DC. Since the ABC transporter MRP1 (ABCC1) was previously shown to play a
van de Ven, R., Groot, J.D., Reurs, A.W., Wijnands, P.G.J.T.B., van de Wetering, K., Schuetz, JD, de Gruijl, T.D., Scheper, R.J., Scheffer, G.L.   +8 more
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Structural insights into human ABCC4-mediated transport of platelet agonist and antagonist

Nature Cardiovascular Research, 2023
Human platelets contribute to hemostasis and thrombosis, the imbalance of which can cause cardiovascular diseases. The activation and accumulation of platelets can be induced by agonists or inhibited by antagonists. Thus, the human ABC transporter ABCC4, which pumps out platelet agonists and antagonists, might become a promising target for preventing ...
Yu Chen, Liang Wang, Wen-Tao Hou, Zhihui Zha, Kang Xu, Cong-Zhao Zhou, Qiong Li, Yuxing Chen   +7 more
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Multidrug resistance protein 4 (MRP4/ABCC4)

Trends in Pharmacological Sciences, 2008
Multidrug resistance protein (MRP) 4 is a member of the MRP/ABCC subfamily of ATP-binding cassette transporters, which are capable of pumping a wide variety of endogenous and xenobiotic organic anionic compounds out of the cell. In addition to its role in the body distribution and renal excretion of a wide variety of antiviral, cytostatic, antibiotic ...
Russel, Frans G M, Koenderink, Jan B, Masereeuw, R.   +2 more
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The ABCC4 gene is a promising target for pancreatic cancer therapy

Gene, 2012
Pancreatic cancer is a malignant neoplasm of the pancreas that usually has a poor prognosis. The investigation of targets that effectively inhibit pancreatic cancer cell proliferation should provide a fundamental basis for the clinical application of gene therapy.
Zhuo, Zhang, Jiancheng, Wang, Baiyong, Shen, Chenghong, Peng, Minhua, Zheng   +4 more
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Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione

The International Journal of Biochemistry & Cell Biology, 2004
Multidrug resistance proteins (MRPs) are ATP-dependent export pumps that mediate the export of organic anions. ABCC1 (MRP1), ABCC2 (MRP2) and ABCC3 (MRP3) are all able to facilitate the efflux of anionic conjugates including glutathione (GSH), glucuronide and sulfate conjugates of xenobiotics and endogenous molecules.
Bai, J., Lai, L., Tan, T.M.C., Yeo, H.C., Goh, B.C.   +4 more
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ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity

Drug Resistance Updates
The role of ABCC4, an ATP-binding cassette transporter, in the process of platelet formation, megakaryopoiesis, is unknown. Here, we show that ABCC4 is highly expressed in megakaryocytes (MKs). Mining of public genomic data (ATAC-seq and genome wide chromatin interactions, Hi-C) revealed that key megakaryopoiesis transcription factors (TFs) interacted ...
Sabina, Ranjit, Yao, Wang, Jingwen, Zhu, Satish B, Cheepala, Erin G, Schuetz, Woo Jung, Cho, Beisi, Xu, Camenzind G, Robinson, Gang, Wu, Anjaparavanda P, Naren, John D, Schuetz   +10 more
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