Results 11 to 20 of about 3,582 (133)

Beneficial effect of ezetimibe-atorvastatin combination therapy in patients with a mutation in ABCG5 or ABCG8 gene

Lipids in Health and Disease, 2020
Background Use of ezetimibe on top of statin therapy has been shown to be effective to reduce LDL cholesterol level in hypercholesterolemic patients. However, little is known regarding the individual variety of the effectiveness of ezetimibe.
Hayato Tada, Hirofumi Okada, Akihiro Nomura, Masayuki Takamura, Masa-aki Kawashiri   +4 more
doaj   +1 more source

تغییرات بیان ژن ABCG8 در سلول‌های PBMN متعاقب هشت هفته تمرین مقاومتی درآب وخشکی درزنان میانسال پس از جراحی بای‌پس عروق کرونری [PDF]

مجله دانشگاه علوم پزشکی سبزوار, 2018
زمینه و هدف: برنامه بازتوانی قلبی در راستای کاهش خطرات ثانویه و افزایش عملکرد بیماران تحت عمل بای پس قلبی طراحی شده که نهایتا با تاخیر و کاهش میزان مرگ و میر قلبی همراه است. یک بخش کلیدی از این برنامه فعالیت ورزشی است.
لیلی ضیاءالدینی دشتخاکی, امیر رشیدلمیر, سعید نقیبی   +2 more
doaj  

Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression

Journal of Lipid Research, 2004
Possible mechanisms for the cholesterol-lowering effects of plant stanol esters were addressed by feeding hamsters diets containing stanol esters, cholesterol, or cholestyramine/lovastatin.
F. Jeffrey Field, Ella Born, Satya N. Mathur   +2 more
doaj   +1 more source

Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice1

Journal of Lipid Research, 2004
In the present study, we investigated whether intestinal sterol efflux transporters Abcg5 and Abcg8 play a major role in determining variations in cholesterol (Ch) absorption efficiency, and we compared the physiological functions of the duodenal ...
Li-Ping Duan, Helen H. Wang, David Q-H. Wang   +2 more
doaj   +1 more source

Multi-analytic approach elucidates significant role of hormonal and hepatocanalicular transporter genetic variants in gallstone disease in North Indian population. [PDF]

PLoS ONE, 2013
OBJECTIVE: Cholesterol gallstone disease (CGD) is a multifactorial and multistep disease. Apart from female gender and increasing age being the documented non-modifiable risk factor for gallstones the pathobiological mechanisms underlying the phenotypic ...
Anshika Srivastava, Avshesh Mishra, Rajan Singh, Rajani Rai, Neena Srivastava, Balraj Mittal   +5 more
doaj   +1 more source

Phytosterolemia on the island of Kosrae

Journal of Lipid Research, 2004
Screening of 932 adults on the Pacific island of Kosrae for plasma plant sterol levels disclosed three subjects, two of them asymptomatic, with phytosterolemia. Sequencing the ATP binding cassette subfamily G member 8 (ABCG8) gene revealed a novel exon 2
Ephraim Sehayek, Hannah J. Yu, Klaus von Bergmann, Dieter Lutjohann, Markus Stoffel, Elizabeth M. Duncan, Laura Garcia-Naveda, Jacqueline Salit, Maude L. Blundell, Jeffrey M. Friedman, Jan L. Breslow   +10 more
doaj   +1 more source

FXR activation promotes intestinal cholesterol excretion and attenuates hyperlipidemia in SR‐B1‐deficient mice fed a high‐fat and high‐cholesterol diet

Physiological Reports, 2020
Obeticholic acid (OCA) activates the farnesoid X receptor (FXR) to lower circulating total cholesterol (TC) and high density lipoprotein‐cholesterol (HDL‐C) concentrations and to stimulate fecal cholesterol excretion in mice by increasing hepatic SR‐B1 ...
Amar B. Singh, Bin Dong, Fredric B. Kraemer, Jingwen Liu   +3 more
doaj   +1 more source

Effects of High-Intensity Resistance Training and Aerobic Exercise on Expression of ABCG4, ABCG5 and ABCG8 Genes in Female Athletes

Medical Laboratory Journal, 2020
Background and objectives: Atherosclerotic cardiovascular disease is the leading cause of death in industrialized countries. High level of plasma lipids including cholesterol and triglycerides is one of the most important risk factors of atherosclerosis.
Reza Bagheri, Samane Darroudi, S Mojtaba Hosseini, Hossein Nikkar, fatemeh khodadadi, somayye kasraee, Mahbube sazegar, Amir Rashidlamir   +7 more
doaj  

Phenotypic heterogeneity of sitosterolemia

Journal of Lipid Research, 2004
Sitosterolemia is a rare autosomal recessive disorder of lipoprotein metabolism characterized by xanthomas and increased plasma concentrations of plant sterols, such as sitosterol.
Jian Wang, Tisha Joy, David Mymin, Jiri Frohlich, Robert A. Hegele   +4 more
doaj   +1 more source

Induction of the intestinal membrane transporters ABCA1 and ABCG8 by 27-hydroxycholesterol through a redox mechanism

Redox Experimental Medicine
Objective: We tested the effect of 27-hydroxycholesterol (27OHC) on the expression and synthesis of two membrane transporters involved in sterols extrusion from the intestinal epithelium into the gut lumen: ATP-binding cassette A1 (ABCA1) and G8 (ABCG8).
Noemi Iaia, Valerio Leoni, Giuseppe Poli, Fiorella Biasi   +3 more
doaj   +1 more source