Results 21 to 30 of about 3,582 (133)

Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8

Journal of Lipid Research, 2002
Mammalian physiological processes can distinguish between dietary cholesterol and non-cholesterol, retaining very little of the non-cholesterol in their bodies.
Kangmo Lu, Mi-Hye Lee, Hongwei Yu, Yuehua Zhou, Shelley A. Sandell, Gerald Salen, Shailendra B. Patel   +6 more
doaj   +1 more source

The rat STSL locus: characterization, chromosomal assignment, and genetic variations in sitosterolemic hypertensive rats

BMC Cardiovascular Disorders, 2003
Background Elevated plant sterol accumulation has been reported in the spontaneously hypertensive rat (SHR), the stroke-prone spontaneously hypertensive rat (SHRSP) and the Wistar-Kyoto (WKY) rat.
Klein Richard, Sato Masao, Egashira Nami, Ikeda Ikuo, Helou Khalil, Lu Kangmo, Lee Mi-Hye, Klett Eric, Pandit Bhaswati, Yu Hongwei, Batta Ashok, Salen Gerald, Patel Shailendra B   +12 more
doaj   +1 more source

Pravastatin Modulate Niemann-Pick C1-Like 1 and ATP-Binding Cassette G5 and G8 to Influence Intestinal Cholesterol Absorption

Journal of Pharmacy & Pharmaceutical Sciences, 2015
Purpose. Niemann-Pick C1-like 1 (NPC1L1), ATP-binding cassette (ABC)G5, and ABCG8 mediate intestinal cholesterol absorption. It is unclear whether pravastatin (PR) or ezetimibe (EZ) affect expression of these transporters.
Atsushi Kawase, Seiji Hata, Mai Takagi, Masahiro Iwaki   +3 more
doaj   +1 more source

Sitosterolemia: A Case Report and a Concise Literature Review

Case Reports in Endocrinology, 2023
Background. Sitosterolemia is a relatively rare metabolism lipid disorder, with about 110 cases worldwide and only a few known cases from the Middle East. Sitosterolemia is characterized by excessive uptake of phytosterols and their deposition in various
Moeber M. Mahzari
doaj   +1 more source

High cholesterol absorption efficiency enhances proatherogenic properties of low‐density lipoprotein particles

Journal of Internal Medicine, Volume 299, Issue 6, Page 711-725, June 2026.
Abstract Background and Aims High cholesterol absorption efficiency is determined by genetic variation in small intestinal sterol transporters and affects one‐third of individuals. Their risk for atherosclerotic cardiovascular disease (ASCVD) is increased compared with low cholesterol absorbers, despite similar serum lipid concentrations.
Katariina Öörni, Lauri Äikäs, Maija Ruuth, Feven Tigistu‐Sahle, Reijo Käkelä, Ingmar Wester, Helena Gylling, Piia Simonen   +7 more
wiley   +1 more source

Association of ABCG5 and ABCG8 Polymorphisms with Gallstone Disease and Gallbladder Cancer

Российский журнал гастроэнтерологии, гепатологии, колопроктологии
Aim: to analyze the role of nucleotide sequence variants (NSVs) of ABCG5 and ABCG8 genes in gallstone disease (GSD) and gallbladder cancer (GBC).Key points. ABCG5 and ABCG8 are key sterol efflux transporters that regulate hepatic secretion and intestinal
I. N. Grigor’eva, T. E. Notova, D. L. Nepomnyashchikh   +2 more
doaj   +1 more source

Association of ATP binding cassette transporter G8 rs4148217 SNP and serum lipid levels in Mulao and Han nationalities

Lipids in Health and Disease, 2012
Background The association of ATP binding cassette transporter G8 gene (ABCG8) rs4148217 single nucleotide polymorphism (SNP) and serum lipid profiles is still controversial in diverse racial/ethnic groups.
Li Qing, Wei Xian-Liang, Yin Rui-Xing
doaj   +1 more source

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

اثر هم‌زمان تمرین هوازی تداومی با شدت متوسط و عصاره سبوس برنج بر بیان ژن‌های ABCG5 و ABCG8 بافت روده در موش‌های صحرایی تغذیه‌شده با غذای چرب [PDF]

مجله علوم پزشکی صدرا
مقدمه: هموستاز کلسترول در مسیر جذب روده‌ای تحت تأثیر بیان ژن‌های متفاوتی مانند ABCG5 و ABCG8 قراردارد، لذا هدف از انجام این مطالعه بررسی تأثیر هوازی تداومی با شدت متوسط و عصاره سبوس برنج بر بیان ژن‌های ABCG5 و ABCG8 بافت روده در موش‌های صحرایی تغذیه‌شده ...
هانیه روانبخش, محمدعلی آذربایجانی, حسین فتح اللهی, مقصود پیری, صالح رحمتی احمدآباد   +4 more
doaj   +1 more source

Dig deeper when it does not make sense: Juvenile xanthomas due to sitosterolemia

JIMD Reports, 2020
Sitosterolemia is an extremely rare autosomal recessive disease caused by mutations in either ABCG5 or ABCG8, which encode for a sterol efflux transporter (sterolin) that pumps sterols out into the intestinal lumen or into bile. This leads to progressive
Sharmila Kiss, Joy Yaplito Lee, James Pitt, Duncan MacGregor, Jane Wallace, Melanie Marty, Natasha J. Brown   +6 more
doaj   +1 more source