Results 251 to 260 of about 3,022,394 (329)
Advanced Science, EarlyView.This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu +10 more
wiley +1 more source
Pancreatico-cutaneous fistula following complicated perforated peptic duodenal ulcer repair. [PDF]
Radiol Case RepAdams R +5 more
europepmc +1 more source
Advanced Science, EarlyView.In SETD2‐mutant ccRCC, the original LEDGF recognition of the H3K36me3 regulatory axis no longer exists. LEDGF interacts with CARM1‐dependent H3R17me2a regulating the transcription of key enzymes in the de novo synthesis pathway. The abnormally elevated LEDGF leads to the accumulation of purine nucleotides in SETD2‐mutant ccRCC, thereby satisfying the ...
Yuwei Zhang +11 more
wiley +1 more source
Acute Perforated Large Bowel Obstruction Due to Colorectal Malignancy: A Surgical Emergency With Options. [PDF]
CureusIkizoglu M, Sahagian M, Roy J, Rhee P.
europepmc +1 more source
Advanced Science, EarlyView.This study elucidates the critical role of Rictor in macrophage activation in acute antibody‐mediated rejection (ABMR). Rictor increases K48‐linked ubiquitination of p65 by upregulating E3 ubiquitin ligase SOCS1, inhibiting transcriptional levels of NLRP3 and inflammasome activation.
Bin Ni +12 more
wiley +1 more source
Diffuse Large B-Cell Lymphoma Presenting With Multiple Episodes of Acute Pancreatitis. [PDF]
CureusPatel PJ, Sokol D.
europepmc +1 more source
Advanced Science, EarlyView.Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun +15 more
wiley +1 more source
Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines
Advanced Science, EarlyView.This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li +11 more
wiley +1 more source
Isolated Superior Mesenteric Arterial Dissection: A Rare Case. [PDF]
CureusBasnet P +4 more
europepmc +1 more source
Mechanical Forces Guide Axon Growth through the Nigrostriatal Pathway in an Organotypic Model
Advanced Science, EarlyView.Nano‐pulling is a magnetic nanoparticle‐based technology for guiding and promoting the axon growth of induced pluripotent stem cell‐derived dopaminergic neurospheres in vitro or neural progenitors transplanted in the brain tissue. Fine control of axon guidance is essential for reconstructing neural networks and restoring functional connectivity in the ...
Sara De Vincentiis +7 more
wiley +1 more source