Results 21 to 30 of about 650 (137)

Abelmoschus manihot alleviates insulin resistance in diabetic kidney disease through attenuation of inflammation [PDF]

BMC Nephrology
Background Emerging evidence implicates insulin resestance (IR) and chronic inflammation as interdependent drivers of diabetic kidney disease (DKD) progression.
Xiansen Wei, Shimin Jiang, Jiao Zhang, Xia Gu, Hongmei Gao, Jian Lu, Wenge Li   +6 more
doaj   +2 more sources

Multi-omics reveals total flavones from Abelmoschus manihot (L.) Medik. [Malvaceae] ameliorate MAFLD via PI3K/AKT/mTOR-mediated autophagy [PDF]

Frontiers in Pharmacology
IntroductionMetabolic-associated fatty liver disease (MAFLD) has emerged as a global health crisis, which is characterized by hepatic lipid accumulation, inflammation, and fibrosis.
Chao Lv, Chao Lv, Chao Lv, Chao Lv, Chao Lv, Lei Zhao, Jiani Hou, Hongyin Sun, Hongyin Sun, Hongyin Sun, Zhongsha Li, Zhongsha Li, Zhongsha Li, Zhongsha Li, Yuesong Wu, Yuesong Wu, Yuesong Wu, Yuesong Wu, Peizheng Shi, Yaping Xiao, Yunjin Xie, Yunjin Xie, Yunjin Xie, Yunjin Xie, Wei Su, Wei Su, Wei Su, Wei Su, Mingzhu Yin, Mingzhu Yin, Mingzhu Yin, Mingzhu Yin   +31 more
doaj   +2 more sources

Total flavonoids from Abelmoschus manihot (L.) improve diabetes nephropathy by regulating the gut–kidney axis [PDF]

Frontiers in Medicine
BackgroundA recent clinical study demonstrated that Huangkui capsule (with its bioactive constituents being total flavones extracted from Abelmoschus manihot (L.), TFA) combined with irbesartan provides effective therapy for type 2 diabetes (T2D ...
Hongmei Yu, Yuanxin Liu, Harvest F. Gu, Harvest F. Gu, Wei Tang, Nan Li   +5 more
doaj   +2 more sources

Integrated analysis of comprehensive metabolomics and network pharmacology to reveal the mechanisms of abelmoschus manihot (L.) medik. in the treatment of cisplatin-induced chronic kidney disease [PDF]

Frontiers in Pharmacology, 2022
Background: Abelmoschus manihot (L.) Medik (“Huangkui” in Chinese, HK) has been widely used for the treatment of kidney diseases. Nephrotoxicity is the side effect of cisplatin (CDDP), which greatly limits its clinical application.
Jian-Cheng Liao, Chang-Yin Li, Feng-Meng Teng, Jian-Chen, Jiang-Yi Yu, Wen-Zheng Ju, Jian-Dong Zou   +6 more
doaj   +2 more sources

Efficacy and safety of Abelmoschus manihot capsule combined with ACEI/ARB on diabetic kidney disease: a systematic review and meta analysis [PDF]

Frontiers in Pharmacology, 2023
Background: Diabetic kidney disease (DKD) is one of the most serious microvascular complications of diabetes, with the incidence rate increasing yearly, which is the leading cause of chronic kidney disease (CKD) and end-stage kidney disease.
Ying Tan, Ying Tan, Ziqi Zhang, Ziqi Zhang, Peipei Zhou, Peipei Zhou, Qiling Zhang, Qiling Zhang, Nan Li, Qianhua Yan, Liji Huang, Jiangyi Yu, Jiangyi Yu   +12 more
doaj   +2 more sources

Metabolomic effects of total flavone of Abelmoschus manihot (L.) medik. on patients with radiation-induced heart disease [PDF]

Scientific Reports
Radiation-induced heart disease (RIHD) is a severe complication of thoracic radiotherapy. Total flavone of Abelmoschus Manihot (L.) Medik. (TFA) demonstrates therapeutic potential on RIHD. However, its metabolic mechanisms remain elusive. This study aims
Ruge Niu, Xiaolong Wang, Qi Jia, Wenqi Zhou, Long Zhang, Zhongchi Xu, Xin Lin   +6 more
doaj   +2 more sources

Integrated metabolomics and 16S rRNA sequencing reveal the mechanism of total flavones of Abelmoschus manihot (L.) Medic against liver fibrosis [PDF]

Scientific Reports
To investigate the therapeutic effect of total flavones of Abelmoschus manihot (L.) Medic (TFA) on CCl4-induced liver fibrosis in mice, and to clarify the mechanism of action of TFA in ameliorating liver fibrosis by untargeted metabolomics and intestinal
Dengya Li, Haitao Ge, Yan Zhang, Shuying Song, Luwan Xing, Emily Heya Tang, Fujiang Wang   +6 more
doaj   +2 more sources

Enrichment and Purification of the Bioactive Flavonoids from Flower of Abelmoschus manihot (L.) Medic Using Macroporous Resins [PDF]

Molecules, 2018
Flower of Abelmoschus manihot (FAM) is clinically effective to treat chronic kidney disease (CKD) with a relatively high dosage. To improve the efficacy and the compliance of patients, macroporous resins were adopted to enrich and purify flavonoids from ...
Zhenzhong Yang, Haitao Tang, Qing Shao, Anna Rita Bilia, Yi Wang, Xiaoping Zhao   +5 more
doaj   +2 more sources

Preparation process and storage stability of Abelmoschus Manihot (L.) medic flowers flavonoids microcapsules [PDF]

Journal of Hebei University of Science and Technology
In order to improve the storage stability and extend the application range of the Abelmoschus Manihot (L.) medic flowers flavonoids(AMF), A.Manihot flowers flavonoids microcapsules (AMFM) were prepared by ultrasonic-assisted embedding-freeze drying ...
Dou ZHAO, Shengnan YANG, Nannan LIU, Yan QIU   +3 more
doaj   +2 more sources

Prospects of Gedi Plant (Abelmoschus manihot L.) as a Functional Food and Herbal Medicine [PDF]

E3S Web of Conferences
Gedi (Abelmoschus manihot L.), is a plant that grows in tropical climates and is widely used as a vegetable and herbal traditional medicine. Many people know gedi as a Japanese papaya.
Indrawati Endang, Setijorini Ludivica Endang   +1 more
doaj   +2 more sources