Results 141 to 150 of about 65,308 (255)

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

Aberrant splicing exonizes C9orf72 repeat expansion in ALS/FTD. [PDF]

Nat Neurosci
Yang S, Wijegunawardana D, Sheth U, Veire AM, Salgado JMS, Arab T, Agrawal M, Zhou J, Pereira JD, Gendron TF, Guo JU.   +10 more
europepmc   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria. [PDF]

Mol Cell
Behera AK, Kim JJ, Kordale S, Pekovic F, Damodaran AP, Kumari B, Vidak S, Dickson E, Xiao MS, Duncan G, Andresson T, Misteli T, Valkov E, Gonatopoulos-Pournatzis T.   +13 more
europepmc   +1 more source

Stargardt disease-associated missense and synonymous ABCA4 variants result in aberrant splicing. [PDF]

Hum Mol Genet, 2023
Kaltak M, Corradi Z, Collin RWJ, Swildens J, Cremers FPM.   +4 more
europepmc   +1 more source

Analysis of Aberrant Splicing Data

Genome Informatics, 2002
Tamada, Yoshinori, Ott, Sascha, Bannai, Hideo, Kim, Sun Yong, Nakai, Kenta, Miyano, Satoru   +5 more
openaire   +1 more source

Trustworthy Multimodal Attention Framework for Creep Rupture Life Prediction Under Data‐Scarce Conditions: A Case Study on IN718

Advanced Science, EarlyView.
An attention‐based multimodal deep learning framework is developed to predict the creep life of Ni‐based superalloys by fusing processing parameters with microstructural micrographs. The model achieves high accuracy (R2 = 0.92), aligns with metallurgical principles by capturing δ‐phase influence, and incorporates uncertainty quantification, offering a ...
Haopeng Lv, Dayong Wu, Ziyuan Rao, Qian Wang, Haikun Ma, Jie Kang, Wang Li, Huicong Dong, Yandong Wang, Zhinan Yang, Ru Su   +10 more
wiley   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Severe Prenatal Presentation of Adenylosuccinate Lyase Deficiency Caused by a Synonymous ADSL Variant Inducing Aberrant Splicing. [PDF]

Prenat Diagn
Klapperich A, Skopova V, Karakaya M, Velmans C, Netzer C, Strizek B, Mrazova LS, Zikanova M.   +7 more
europepmc   +1 more source

Aberrant splicing of PSEN2, but not PSEN1, in individuals with sporadic Alzheimer's disease. [PDF]

Brain, 2023
Course MM, Gudsnuk K, Keene CD, Bird TD, Jayadev S, Valdmanis PN.   +5 more
europepmc   +1 more source