The nexus of long noncoding RNAs, splicing factors, alternative splicing and their modulations [PDF]
RNA Biology, 2023 The process of alternative splicing (AS) is widely deregulated in a variety of cancers. Splicing is dependent upon splicing factors. Recently, several long noncoding RNAs (lncRNAs) have been shown to regulate AS by directly/indirectly interacting with ...
Pushkar Malakar +4 more
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Regulation of Pre-mRNA Splicing: Indispensable Role of Post-Translational Modifications of Splicing Factors [PDF]
Life, 2023 Pre-mRNA splicing is a process used by eukaryotic cells to generate messenger RNAs that can be translated into proteins. During splicing, the non-coding regions of the RNAs (introns) are removed from pre-mRNAs and the coding regions (exons) are joined ...
Miroslava Kretova +3 more
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CRISPR artificial splicing factors [PDF]
Nature Communications, 2020 Control over splicing could be used for both therapeutic and engineering applications. Here the authors create artificial splicing factors using RNA-targeting CRISPR systems under small molecule control.
Menghan Du +4 more
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An overview of RNA splicing and functioning of splicing factors in land plant chloroplasts
RNA Biology, 2022 RNA splicing refers to a process by which introns of a pre-mRNA are excised and the exons at both ends are joined together. Chloroplast introns are inherently self-splicing ribozymes, but over time, they have lost self-splicing ability due to the ...
Xuemei Wang +4 more
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Targeting splicing factors for cancer therapy. [PDF]
RNA, 2023 Alternative splicing (AS) of mRNAs is an essential regulatory mechanism in eukaryotic gene expression. AS misregulation, caused by either dysregulation or mutation of splicing factors, has been shown to be involved in cancer development and progression, making splicing factors suitable targets for cancer therapy.
Bashari A, Siegfried Z, Karni R.
europepmc +3 more sources
The Role of Splicing Factors in Adipogenesis and Thermogenesis. [PDF]
Mol Cells, 2023 Obesity is a significant global health risk that can cause a range of serious metabolic problems, such as type 2 diabetes and cardiovascular diseases. Adipose tissue plays a pivotal role in regulating energy and lipid storage. New research has underlined the crucial role of splicing factors in the physiological and functional regulation of adipose ...
Naing YT, Sun L.
europepmc +3 more sources
Updated Progress on Group II Intron Splicing Factors in Plant Chloroplasts [PDF]
Current Issues in Molecular Biology, 2022 Group II introns are large catalytic RNAs (ribozymes) in the bacteria and organelle genomes of several lower eukaryotes. Many critical photosynthesis-related genes in the plant chloroplast genome also contain group II introns, and their splicing is ...
Chu Zeng +3 more
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MALAT1 modulates alternative splicing by cooperating with the splicing factors PTBP1 and PSF. [PDF]
Sci Adv, 2022 Understanding how long noncoding RNAs (lncRNAs) cooperate with splicing factors (SFs) in alternative splicing (AS) control is fundamental to human biology and disease. We show that metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a well-documented AS-implicated lncRNA, regulates AS via two SFs, polypyrimidine tract–binding protein 1 ...
Miao H +11 more
europepmc +3 more sources
Identification of alternative splicing regulatory patterns and characteristic splicing factors in heart failure using RNA-seq data and machine learning [PDF]
HeliyonHeart failure (HF) represents the advanced stage of several cardiovascular disorders. This study aimed to build an alternative splicing regulatory network and identify potential splicing factors involved in HF utilizing RNA-seq data and machine learning ...
Jia Li +4 more
doaj +2 more sources
Differential recruitment of pre-mRNA splicing factors to alternatively spliced transcripts in vivo. [PDF]
PLoS Biology, 2005 Alternative splicing in mammalian cells has been suggested to be largely controlled by combinatorial binding of basal splicing factors to pre-mRNA templates.
Stephen A Mabon, Tom Misteli
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