Results 21 to 30 of about 215,491 (295)

Splicing-factor alterations in cancers [PDF]

RNA, 2016
Tumor-associated alterations in RNA splicing result either from mutations in splicing-regulatory elements or changes in components of the splicing machinery. This review summarizes our current understanding of the role of splicing-factor alterations in human cancers.
Anczuków, Olga, Krainer, Adrian R
openaire   +2 more sources

Regulation of RNA Splicing: Aberrant Splicing Regulation and Therapeutic Targets in Cancer

Cells, 2021
RNA splicing is a critical step in the maturation of precursor mRNA (pre-mRNA) by removing introns and exons. The combination of inclusion and exclusion of introns and exons in pre-mRNA can generate vast diversity in mature mRNA from a limited number of ...
Koji Kitamura, Keisuke Nimura
doaj   +1 more source

Splicing factor mutations and cancer [PDF]

WIREs RNA, 2014
Recent advances in high‐throughput sequencing technologies have unexpectedly revealed that somatic mutations of splicing factor genes frequently occurred in several types of hematological malignancies, including myelodysplastic syndromes, other myeloid neoplasms, and chronic lymphocytic leukemia.
Yoshida, Kenichi, Ogawa, Seishi
openaire   +2 more sources

The proper splicing of RNAi factors is critical for pericentric heterochromatin assembly in fission yeast. [PDF]

PLoS Genetics, 2014
Heterochromatin preferentially assembles at repetitive DNA elements, playing roles in transcriptional silencing, recombination suppression, and chromosome segregation.
Scott P Kallgren, Stuart Andrews, Xavier Tadeo, Haitong Hou, James J Moresco, Patricia G Tu, John R Yates, Peter L Nagy, Songtao Jia   +8 more
doaj   +1 more source

Splicing Players Are Differently Expressed in Sporadic Amyotrophic Lateral Sclerosis Molecular Clusters and Brain Regions

Cells, 2020
Splicing is a tightly orchestrated process by which the brain produces protein diversity over time and space. While this process specializes and diversifies neurons, its deregulation may be responsible for their selective degeneration.
Valentina La Cognata, Giulia Gentile, Eleonora Aronica, Sebastiano Cavallaro   +3 more
doaj   +1 more source

Incorporating evolutionary information and functional domains for identifying RNA splicing factors in humans. [PDF]

PLoS ONE, 2011
Regulation of pre-mRNA splicing is achieved through the interaction of RNA sequence elements and a variety of RNA-splicing related proteins (splicing factors).
Justin Bo-Kai Hsu, Neil Arvin Bretaña, Tzong-Yi Lee, Hsien-Da Huang   +3 more
doaj   +1 more source

The Role of RNA Splicing Factors in Cancer: Regulation of Viral and Human Gene Expression in Human Papillomavirus-Related Cervical Cancer

Frontiers in Cell and Developmental Biology, 2020
The spliceosomal complex components, together with the heterogeneous nuclear ribonucleoproteins (hnRNPs) and serine/arginine-rich (SR) proteins, regulate the process of constitutive and alternative splicing, the latter leading to the production of mRNA ...
Andrea Cerasuolo, Luigi Buonaguro, Franco M. Buonaguro, Maria Lina Tornesello   +3 more
doaj   +1 more source

Modulation of the Host Nuclear Compartment by Trypanosoma cruzi Uncovers Effects on Host Transcription and Splicing Machinery

Frontiers in Cellular and Infection Microbiology, 2021
Host manipulation is a common strategy for invading pathogens. Trypanosoma cruzi, the causative agent of Chagas Disease, lives intracellularly within host cells.
Camila Gachet-Castro, Felipe Freitas-Castro, Raul Alexander Gonzáles-Córdova, Carol Kobori da Fonseca, Marcelo Damário Gomes, Hellen Cristina Ishikawa-Ankerhold, Munira Muhammad Abdel Baqui   +6 more
doaj   +1 more source

Exploring the Diverse Functional and Regulatory Consequences of Alternative Splicing in Development and Disease

Frontiers in Genetics, 2021
Alternative splicing is a fundamental mechanism of eukaryotic RNA regulation that increases the transcriptomic and proteomic complexity within an organism.
M. Brandon Titus, Adeline W. Chang, Eugenia C. Olesnicky   +2 more
doaj   +1 more source

Proteomic study identifies Aurora-A-mediated regulation of alternative splicing through multiple splicing factors. [PDF]

J Biol Chem
International audienceThe cell cycle regulator Aurora-A kinase presents an attractive target for cancer therapies, though its inhibition is also associated with toxic side effects.
Damodaran AP, Gavard O, Gagné JP, Rogalska ME, Behera AK, Mancini E, Bertolin G, Courtheoux T, Kumari B, Cailloce J, Mereau A, Poirier GG, Valcárcel J, Gonatopoulos-Pournatzis T, Watrin E, Prigent C.   +15 more
europepmc   +3 more sources