Results 41 to 50 of about 215,491 (295)
Unraveling the Molecular Mechanism of Splicing through Molecular Dynamics Simulation [PDF]
, 2021 The genes architecture as made of intron and exons is now a widely accepted fact and a well-established hypothesis. Indeed, the exons regions of a DNA molecule that code for proteins are not a continuous unitary sequence, but silent intervening segments (
Saltalamacchia, Andrea
core
Survival-Associated Alternative Splicing Events and Prognostic Signatures in Pancreatic Cancer
Frontiers in Genetics, 2020 BackgroundAlternative splicing (AS) is reported to be related to the biological process of multiple malignancies. This study is conducted to identify survival-associated AS events and prognostic signatures that may serve as prognostic indicators for ...
Lichao Xu +4 more
doaj +1 more source
Systematic Analysis of Survival-Associated Alternative Splicing Signatures in Thyroid Carcinoma
Frontiers in Oncology, 2021 Alternative splicing (AS) is a key mechanism involved in regulating gene expression and is closely related to tumorigenesis. The incidence of thyroid cancer (THCA) has increased during the past decade, and the role of AS in THCA is still unclear.
Baoai Han +10 more
doaj +1 more source
Robust and annotation-free analysis of alternative splicing across diverse cell types in mice
eLife, 2022 Although alternative splicing is a fundamental and pervasive aspect of gene expression in higher eukaryotes, it is often omitted from single-cell studies due to quantification challenges inherent to commonly used short-read sequencing technologies. Here,
Gonzalo Benegas +2 more
doaj +1 more source
Nucleocytoplasmic Shuttling of the Splicing Factor SIPP1 [PDF]
Journal of Biological Chemistry, 2005 SIPP1 (splicing factor that interacts with PQBP1 and PP1) is a widely expressed protein of 70 kDa that has been implicated in pre-mRNA splicing. It interacts with protein Ser/Thr phosphatase-1 (PP1) and with the polyglutamine-tract-binding protein 1 (PQBP1), which contributes to the pathogenesis of X-linked mental retardation and neurodegenerative ...
Miriam, Llorian +7 more
openaire +2 more sources
Epigenetic Regulation of Alternative Splicing: How LncRNAs Tailor the Message
Non-Coding RNA, 2021 Alternative splicing is a highly fine-tuned regulated process and one of the main drivers of proteomic diversity across eukaryotes. The vast majority of human multi-exon genes is alternatively spliced in a cell type- and tissue-specific manner, and ...
Giuseppina Pisignano, Michael Ladomery
doaj +1 more source
Functional roles of protein splicing factors [PDF]
Bioscience Reports, 2012 RNA splicing is one of the fundamental processes in gene expression in eukaryotes. Splicing of pre-mRNA is catalysed by a large ribonucleoprotein complex called the spliceosome, which consists of five small nuclear RNAs and numerous protein factors. The spliceosome is a highly dynamic structure, assembled by sequential binding and release of the small ...
Chen, Hsin-Chou, Cheng, Soo-Chen
openaire +2 more sources
Frontiers in Cellular and Infection Microbiology, 2022 Rift Valley fever virus (RVFV) is an emerging pathogen that has potential to cause severe disease in humans and domestic livestock. Propagation of RVFV strain MP-12 is negatively impacted by the actions of RIOK3, a protein involved in the cellular immune
Luke Adam White +6 more
doaj +1 more source
Operon conservation and the evolution of trans-splicing in the phylum Nematoda [PDF]
, 2006 The nematode Caenorhabditis elegans is unique among model animals in that many of its genes are cotranscribed as polycistronic pre-mRNAs from operons.
Mark L Blaxter +5 more
core +1 more source
PLoS ONE, 2010 BackgroundClear cell renal cell carcinoma (ccRCC) is the most common type of renal cancer. One of the processes disturbed in this cancer type is alternative splicing, although phenomena underlying these disturbances remain unknown.
Agnieszka Piekielko-Witkowska +6 more
doaj +1 more source