Results 51 to 60 of about 215,491 (295)

Interactions of the Yeast SF3b Splicing Factor [PDF]

Molecular and Cellular Biology, 2005
The U2 snRNP promotes prespliceosome assembly through interactions that minimally involve the branchpoint binding protein, Mud2p, and the pre-mRNA. We previously showed that seven proteins copurify with the yeast (Saccharomyces cerevisiae) SF3b U2 subcomplex that associates with the pre-mRNA branchpoint region: Rse1p, Hsh155p, Hsh49p, Cus1p, and Rds3p ...
Qiang, Wang, Jin, He, Bert, Lynn, Brian C, Rymond   +3 more
openaire   +2 more sources

Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity. [PDF]

, 1997
Published ...
Cáceres, J. F., Misteli, T, Spector, DL, Javier F. Cáceres, Cáceres, JF, Krainer, AR, Screaton, G. R., Spector, D. L., Tom Misteli, Adrian R. Krainer, Krainer, A. R., Gavin R. Screaton, Screaton, GR, David L. Spector, Misteli, T.   +14 more
core   +1 more source

Moonlighting in Mitosis: Analysis of the Mitotic Functions of Transcription and Splicing Factors

Cells, 2020
Moonlighting proteins can perform one or more additional functions besides their primary role. It has been posited that a protein can acquire a moonlighting function through a gradual evolutionary process, which is favored when the primary and secondary ...
Maria Patrizia Somma, Evgeniya N. Andreyeva, Gera A. Pavlova, Claudia Pellacani, Elisabetta Bucciarelli, Julia V. Popova, Silvia Bonaccorsi, Alexey V. Pindyurin, Maurizio Gatti   +8 more
doaj   +1 more source

Temporal Dynamic Analysis of Alternative Splicing During Embryonic Development in Zebrafish

Frontiers in Cell and Developmental Biology, 2022
Alternative splicing is pervasive in mammalian genomes and involved in embryo development, whereas research on crosstalk of alternative splicing and embryo development was largely restricted to mouse and human and the alternative splicing regulation ...
Zhe Liu, Wei Wang, Xinru Li, Xinru Li, Xiujuan Zhao, Hongyu Zhao, Wuritu Yang, Wuritu Yang, Yongchun Zuo, Yongchun Zuo, Lu Cai, Yongqiang Xing   +11 more
doaj   +1 more source

A splicing-dependent transcriptional checkpoint associated with prespliceosome formation

, 2014
There is good evidence for functional interactions between splicing and transcription in eukaryotes, but how and why these processes are coupled remain unknown.
Chathoth, Keerthi T, Webb, Shaun, Barrass, J David, Beggs, Jean D   +3 more
core   +1 more source

Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 nuclear bodies [PDF]

, 2009
Background: Active pre-mRNA splicing occurs co-transcriptionally, and takes place throughout the nucleoplasm of eukaryotic cells. Splicing decisions are controlled by networks of nuclear RNA-binding proteins and their target sequences, sometimes in ...
Rajan, P., Heiner, M., Leung, Hing, Dalgliesh, C., Bindereif, A, David J Elliott, Dalgliesh, C, Craig N Robson, Dalgliesh Caroline, Elliott, David, Kaveh Emami, Bindereif, A., Heiner Monika, Emami, K, Clark, E.L., Hing Y Leung, Elliott, D.J., Elliott, DJ, Rajan, Prabhakar, Leung Hing Y, Heiner, M, Bourgeois, C.F., Rajan, P, Prabhakar Rajan, Emami, K., Leung, H.Y., Elliott David J, Stevenin James, Stevenin, J., Clark Emma L, Emami, Kaveh, Bindereif, Albrecht, Bourgeois, CF, Bindereif Albrecht, Cyril F Bourgeois, Robson, C.N., Bourgeois, Cyril F, Prabhakar Rajan, Albrecht Bindereif, Heiner, Monika, Caroline Dalgliesh, Robson Craig N, Robson, Craig, Emma L Clark, Clark, EL, Dalgliesh, Caroline, Stevenin, J, Leung, HY, Stevenin, James, Robson, CN, Rajan Prabhakar, Bourgeois Cyril F, Emami Kaveh, Monika Heiner, James Stevenin, Clark, Emma   +55 more
core   +1 more source

The emerging role of splicing factors in cancer [PDF]

EMBO reports, 2008
Recent progress in global sequence and microarray data analysis has revealed the increasing complexity of the human transcriptome. Alternative splicing generates a huge diversity of transcript variants and disruption of splicing regulatory networks is emerging as an important contributor to various diseases, including cancer.
Ana Rita, Grosso, Sandra, Martins, Maria, Carmo-Fonseca   +2 more
openaire   +2 more sources

Hypoxia-induced alternative splicing in endothelial cells

, 2012
Background: Adaptation to low oxygen by changing gene expression is vitally important for cell survival and tissue development. The sprouting of new blood vessels, initiated from endothelial cells, restores the oxygen supply of ischemic tissues.
Weigand, Julia E., Julia E. Weigand (17017), Julia E Weigand, Pascal Gellert, Stefanie Dimmeler, Dimmeler, Stefanie, Jes-Niels Boeckel (145707), Pascal Gellert (145710), Gellert, Pascal, Jes-Niels Boeckel, Stefanie Dimmeler (134234), Boeckel, Jes-Niels   +11 more
core   +1 more source

A novel Splicing Factor that Affects Titin Alternative Splicing [PDF]

Biophysical Journal, 2011
Cardiac muscle expresses predominantly larger N2BA titin isoforms at embryonic and prenatal stages of development, and these are mostly replaced with a smaller N2B isoform in adults. We have previously discovered a mutation in rats that dramatically alters titin splicing (Greaser et al J Mol Cell Cardiol 44:982, 2008).
Guo, Wei, Greaser, Marion, Li, Shijun, Schulz, Herbert, Saar, Kathrin, Radke, Michael, Hacker, Timothy A., Saupe, Kurt W., Vakeel, Padmanabhan, Govindarajan, Thirupugal, Hubner, Norbert, Gotthardt, Michael   +11 more
openaire   +1 more source

Biological relevance of alternative splicing in hematologic malignancies

Molecular Medicine
Alternative splicing (AS) is a strictly regulated process that generates multiple mRNA variants from a single gene, thus contributing to proteome diversity.
Monika Szelest, Krzysztof Giannopoulos
doaj   +1 more source