Results 71 to 80 of about 215,491 (295)

Regulation of the alternative splicing of Dp71, the major brain dystrophin transcript, by splicing factors [PDF]

, 2021
Duchenne muscular dystrophy (DMD) is a fatal childhood genetic disorder, caused by the absence of dystrophin throughout the body. Parallel to muscle degradation, loss of dystrophin in the brain can lead to cognitive impairments and intellectual ...
Anthony, Karen, Wood, Chelsea
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Identification of Survival-Associated Alternative Splicing Signatures in Lung Squamous Cell Carcinoma

Frontiers in Oncology, 2020
Purpose: Alternative splicing (AS) is a post-transcriptional process that plays a significant role in enhancing the diversity of transcription and protein.
Yang Liu, Wenxiao Jia, Ji Li, Ji Li, Hui Zhu, Jinming Yu   +5 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Predicting the Impact of Alternative Splicing on Plant MADS Domain Protein Function

, 2012
Several genome-wide studies demonstrated that alternative splicing (AS) significantly increases the transcriptome complexity in plants. However, the impact of AS on the functional diversity of proteins is difficult to assess using genome-wide approaches.
Morabito, G., Dijk, A.D.J., van, Severing, E.I., Busscher-Lange, J., Ham, R.C.H.J., van, Immink, G.H.   +5 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing [PDF]

, 2012
Increasing evidence suggests that chromatin modifications have important roles in modulating constitutive or alternative splicing. Here we demonstrate that the PWWP domain of the chromatin-associated protein Psip1/Ledgf can specifically recognize tri ...
Grimes, GR, Pradeepa Madapura M., Heidi G. Sutherland (164829), Jernej Ule, Wendy A. Bickmore (42659), Pradeepa, MM, Ule, Jernej, Bickmore Wendy A., Sutherland, Heidi G., Heidi G Sutherland, Bickmore, Wendy A, Bickmore, WA, Madapura M. Pradeepa (164826), Grimes, Graeme R., Bickmore, Wendy A., Grimes Graeme R., Ule, J, Madapura M Pradeepa, Ule Jernej, Pradeepa, Madapura M, Grimes, Graeme R, Sutherland, Heidi G, Pradeepa, Madapura M., Sutherland, HG, Wendy A Bickmore, Graeme R Grimes, Sutherland Heidi G., Graeme R. Grimes (164833), Madapura, Pradeepa, Jernej Ule (115588)   +29 more
core   +1 more source

Best evidence linking the extracellular factor TGF-β to cancer-associated alternative splicing programs

BBA Advances
Alternative splicing is a mechanism by which several RNA transcripts can be created from one gene. Splicing factors are RNA binding proteins recognizing cis-acting sequences that positively or negatively influence the splicing decision based on their ...
Opeoluwa Alli-Oke, Jean-Philippe Brosseau   +1 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Post-transcriptional regulation of 5-lipoxygenase mRNA expression via alternative splicing and nonsense-mediated mRNA decay

, 2012
5-Lipoxygenase (5-LO) catalyzes the two initial steps in the biosynthesis of leukotrienes (LT), a group of inflammatory lipid mediators derived from arachidonic acid.
Laura Pufahl (182448), Manuel Grez, Grez, Manuel, Ochs, Meike J., Sorg, Bernd L., Beatrix Suess (17019), Sorg Bernd L., Laura Pufahl, Sorg, Bernd Lothar, Bernd L Sorg, Beatrix Suess, Bernd L. Sorg (182441), Suess Beatrix, Grez Manuel, Steinhilber Dieter, Dieter Steinhilber (182458), Meike J. Ochs (182432), Suess, Beatrix, Manuel Grez (182453), Dieter Steinhilber, Meike J Ochs, Pufahl, Laura, Süß, Beatrix, Pufahl Laura, Ochs, Meike, Steinhilber, Dieter, Ochs Meike J.   +26 more
core   +1 more source