Results 11 to 20 of about 215,491 (295)
Engineering splicing factors with designed specificities [PDF]
Nature Methods, 2009 Alternative splicing is generally regulated by trans-acting factors that specifically bind pre-mRNA to activate or inhibit the splicing reaction. This regulation is critical for normal gene expression, and dysregulation of splicing is closely associated with human diseases. Here we engineer artificial splicing factors by combining sequence-specific RNA-
Yang, Wang +3 more
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Aurora-A phosphorylates splicing factors and regulates alternative splicing [PDF]
, 2020 ABSTRACT Aurora-A kinase is well known to regulate progression through mitosis. However, the kinase also performs additional functions that could explain the failure of its inhibitors to be effective in cancer treatments. To identify these functions, we applied a proteomics approach to search for interactors of Aurora-
Arun Prasath Damodaran +11 more
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Splicing factors in the heart: Uncovering shared and unique targets
Journal of Molecular and Cellular Cardiology, 2023 Alternative splicing generates specialized protein isoforms that allow the heart to adapt during development and disease. The recent discovery that mutations in the splicing factor RNA-binding protein 20 (RBM20) cause a severe form of familial dilated cardiomyopathy has sparked a great interest in alternative splicing in the field of cardiology.
Montañés-Agudo, Pablo +2 more
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Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors [PDF]
The Journal of cell biology, 1994 We have examined the functional significance of the organization of pre-mRNA splicing factors in a speckled distribution in the mammalian cell nucleus. Upon microinjection into living cells of oligonucleotides or antibodies that inhibit pre-mRNA splicing in vitro, we observed major changes in the organization of splicing factors in vivo. Interchromatin
O'Keefe, Raymond T.; id_orcid 0000-0001-8764-1289 +4 more
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Plants, 2023 We investigated the transcriptomic changes in the shoot apices during floral transition in Arabidopsis mutants of two closely related splicing factors: AtU2AF65a (atu2af65a) and AtU2AF65b (atu2af65b).
Hee Tae Lee +4 more
doaj +1 more source
Age-Related Alternative Splicing: Driver or Passenger in the Aging Process?
Cells, 2023 Alternative splicing changes are closely linked to aging, though it remains unclear if they are drivers or effects. As organisms age, splicing patterns change, varying gene isoform levels and functions.
Marco Baralle, Maurizio Romano
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Processive phosphorylation of alternative splicing factor/splicing factor 2 [PDF]
Proceedings of the National Academy of Sciences, 2003 SR proteins, named for their multiple arginine/serine (RS) dipeptide repeats, are critical components of the spliceosome, influencing both constitutive and alternative splicing of pre-mRNA. SR protein function is regulated through phosphorylation of their RS domains by multiple kinases, including a family of evolutionarily conserved SR protein-specific
Brandon E, Aubol +7 more
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Splicing factor mutations in hematologic malignancies [PDF]
Blood, 2021 Abstract Mutations in genes encoding RNA splicing factors were discovered nearly 10 years ago and are now understood to be among the most recurrent genetic abnormalities in patients with all forms of myeloid neoplasms and several types of lymphoproliferative disorders, as well as subjects with clonal hematopoiesis.
Sisi Chen +2 more
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RNA splicing alterations in lung cancer pathogenesis and therapy
Cancer Pathogenesis and Therapy, 2023 RNA splicing alterations are widespread and play critical roles in cancer pathogenesis and therapy. Lung cancer is highly heterogeneous and causes the most cancer-related deaths worldwide.
Yueren Yan +3 more
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Alternative Splicing Events and Splicing Factors Are Prognostic in Adrenocortical Carcinoma [PDF]
Frontiers in Genetics, 2020 Alternative splicing is involved in the pathogenesis of human diseases, including cancer. Here, we investigated the potential application of alternative splicing events (ASEs) and splicing factors (SFs) in the prognosis of adrenocortical carcinoma (ACC).
Jian Lv +5 more
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