Results 11 to 20 of about 7,687,875 (261)
CRISPR artificial splicing factors [PDF]
Nature Communications, 2020 Control over splicing could be used for both therapeutic and engineering applications. Here the authors create artificial splicing factors using RNA-targeting CRISPR systems under small molecule control.
Menghan Du +4 more
doaj +2 more sources
Updated Progress on Group II Intron Splicing Factors in Plant Chloroplasts
Current Issues in Molecular Biology, 2022 Group II introns are large catalytic RNAs (ribozymes) in the bacteria and organelle genomes of several lower eukaryotes. Many critical photosynthesis-related genes in the plant chloroplast genome also contain group II introns, and their splicing is ...
Chu Zeng +3 more
doaj +1 more source
Cells, 2020 Splicing is a tightly orchestrated process by which the brain produces protein diversity over time and space. While this process specializes and diversifies neurons, its deregulation may be responsible for their selective degeneration.
Valentina La Cognata +3 more
doaj +1 more source
Incorporating evolutionary information and functional domains for identifying RNA splicing factors in humans. [PDF]
PLoS ONE, 2011 Regulation of pre-mRNA splicing is achieved through the interaction of RNA sequence elements and a variety of RNA-splicing related proteins (splicing factors).
Justin Bo-Kai Hsu +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 The spliceosomal complex components, together with the heterogeneous nuclear ribonucleoproteins (hnRNPs) and serine/arginine-rich (SR) proteins, regulate the process of constitutive and alternative splicing, the latter leading to the production of mRNA ...
Andrea Cerasuolo +3 more
doaj +1 more source
Systematic Analysis of Survival-Associated Alternative Splicing Signatures in Thyroid Carcinoma
Frontiers in Oncology, 2021 Alternative splicing (AS) is a key mechanism involved in regulating gene expression and is closely related to tumorigenesis. The incidence of thyroid cancer (THCA) has increased during the past decade, and the role of AS in THCA is still unclear.
Baoai Han +10 more
doaj +1 more source
Robust and annotation-free analysis of alternative splicing across diverse cell types in mice
eLife, 2022 Although alternative splicing is a fundamental and pervasive aspect of gene expression in higher eukaryotes, it is often omitted from single-cell studies due to quantification challenges inherent to commonly used short-read sequencing technologies. Here,
Gonzalo Benegas +2 more
doaj +1 more source
Epigenetic Regulation of Alternative Splicing: How LncRNAs Tailor the Message
Non-Coding RNA, 2021 Alternative splicing is a highly fine-tuned regulated process and one of the main drivers of proteomic diversity across eukaryotes. The vast majority of human multi-exon genes is alternatively spliced in a cell type- and tissue-specific manner, and ...
Giuseppina Pisignano, Michael Ladomery
doaj +1 more source
Perturbation of chromatin structure globally affects localization and recruitment of splicing factors [PDF]
, 2012 Chromatin structure is an important factor in the functional coupling between transcription and mRNA processing, not only by regulating alternative splicing events, but also by contributing to exon recognition during constitutive splicing.
Risso, Guillermo, J +47 more
core +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Rift Valley fever virus (RVFV) is an emerging pathogen that has potential to cause severe disease in humans and domestic livestock. Propagation of RVFV strain MP-12 is negatively impacted by the actions of RIOK3, a protein involved in the cellular immune
Luke Adam White +6 more
doaj +1 more source