Results 21 to 30 of about 65,308 (255)

Therapeutic Targeting of Alternative Splicing: A New Frontier in Cancer Treatment

Frontiers in Oncology, 2022
The ability for cells to harness alternative splicing enables them to diversify their proteome in order to carry out complex biological functions and adapt to external and internal stimuli. The spliceosome is the multiprotein-RNA complex charged with the
Anthony J. Murphy, Alex H. Li, Peichao Li, Hong Sun   +3 more
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Aberrant RNA splicing and therapeutic opportunities in cancers [PDF]

Cancer Science, 2021
AbstractThere has been accumulating evidence that RNA splicing is frequently dysregulated in a variety of cancers and that hotspot mutations affecting key splicing factors, SF3B1, SRSF2 and U2AF1, are commonly enriched across cancers, strongly suggesting that aberrant RNA splicing is a new class of hallmark that contributes to the initiation and/or ...
Hirofumi Yamauchi, Kazuki Nishimura, Akihide Yoshimi   +2 more
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Aberrant splicing isoforms detected by full-length transcriptome sequencing as transcripts of potential neoantigens in non-small cell lung cancer

Genome Biology, 2021
Background Long-read sequencing of full-length cDNAs enables the detection of structures of aberrant splicing isoforms in cancer cells. These isoforms are occasionally translated, presented by HLA molecules, and recognized as neoantigens. This study used
Miho Oka, Liu Xu, Toshihiro Suzuki, Toshiaki Yoshikawa, Hiromi Sakamoto, Hayato Uemura, Akiyasu C. Yoshizawa, Yutaka Suzuki, Tetsuya Nakatsura, Yasushi Ishihama, Ayako Suzuki, Masahide Seki   +11 more
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The aberrant splicing of BAF45d links splicing regulation and transcription in glioblastoma [PDF]

Neuro-Oncology, 2018
Glioblastoma, the most aggressive primary brain tumor, is genetically heterogeneous. Alternative splicing (AS) plays a key role in numerous pathologies, including cancer. The objectives of our study were to determine whether aberrant AS could play a role in the malignant phenotype of glioma and to understand the mechanism underlying its aberrant ...
Aldave G, Gonzalez-Huarriz M, Rubio A, Romero JP, Ravi D, Minana B, Cuadrado-Tejedor M, Garcia-Osta A, Verhaak R, Xipell E, Martinez-Velez N, de la Rocha AA, Puigdelloses M, Garcia-Moure M, Marigil M, Perez-Larraya JG, Marin-Bejar O, Huarte M, CARRO M, Ferrarese R, Belda-Iniesta C, Ayuso A, Prat-Acin R, Pastor F, Diez-Valle R, Tejada S, Alonso MM   +26 more
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Alternative splicing in breast cancer

Journal of Bio-X Research, 2023
Alternative splicing allows a gene to produce multiple proteins and is the main source of human proteome diversity. Aberrant regulation of alternative splicing produces proteins with different structures and can lead to altered protein function ...
Xin Wen, Ze Yan, Li Sha
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Retroviral Splicing Suppressor Sequesters a 3′ Splice Site in a 50S Aberrant Splicing Complex [PDF]

Molecular and Cellular Biology, 2005
Retroviral replication requires both spliced and unspliced mRNAs. Splicing suppression of avian retroviral RNA depends in part upon a cis-acting element within the gag gene called the negative regulator of splicing (NRS). The NRS, linked to a downstream intron and exon (NRS-Ad3'), was not capable of splicing in vitro.
Keith E, Giles, Karen L, Beemon
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Silent disruption: aberrant splicing in VWD [PDF]

Blood, 2016
In this issue of Blood, Yadegari et al1 report in a patient with type 1 von Willebrand disease (VWD) a novel synonymous von Willebrand factor (VWF) genetic variant and aberrant VWF splicing mechanism leading to VWF mRNA intron retention. The index patient presented with mucosal and provoked bleeding and low VWF level (VWF:Ag) and activity (VWF:GPIb) of
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Aberrant Bcl-x splicing in cancer: from molecular mechanism to therapeutic modulation

Journal of Experimental & Clinical Cancer Research, 2021
Bcl-x pre-mRNA splicing serves as a typical example to study the impact of alternative splicing in the modulation of cell death. Dysregulation of Bcl-x apoptotic isoforms caused by precarious equilibrium splicing is implicated in genesis and development ...
Zhihui Dou, Dapeng Zhao, Xiaohua Chen, Caipeng Xu, Xiaodong Jin, Xuetian Zhang, Yupei Wang, Xiaodong Xie, Qiang Li, Cuixia Di, Hong Zhang   +10 more
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Alternative Splicing: A New Cause and Potential Therapeutic Target in Autoimmune Disease

Frontiers in Immunology, 2021
Alternative splicing (AS) is a complex coordinated transcriptional regulatory mechanism. It affects nearly 95% of all protein-coding genes and occurs in nearly all human organs.
Pingping Ren, Pingping Ren, Pingping Ren, Luying Lu, Luying Lu, Luying Lu, Shasha Cai, Shasha Cai, Jianghua Chen, Jianghua Chen, Jianghua Chen, Weiqiang Lin, Weiqiang Lin, Weiqiang Lin, Weiqiang Lin, Fei Han, Fei Han, Fei Han   +17 more
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Aberrant Alternative Splicing Events in Parkinson's Disease [PDF]

Cell Transplantation, 2013
Alternative splicing (AS) using a sole gene to express multiple transcripts with diverse protein coding sequences and/or RNA regulatory elements raises genomic complexities. In the nervous system, several thousand AS events play important roles in ion transportation, receptor recognition, neurotransmission, memory, and learning.
Ru-Huei Fu, Shih-Ping Liu, Shyh-Jer Huang, Hung-Jen Chen, Pin-Ru Chen, Ya-Hsien Lin, Yu-Chen Ho, Wen-Lin Chang, Chang-Hai Tsai, Woei-Cherng Shyu, Shinn-Zong Lin M.D., Ph.D.   +10 more
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