Results 161 to 170 of about 509,731 (381)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging [PDF]

, 2018
Siren Tønnesen, Tobias Kaufmann, Nhat Trung Doan, Dag Alnæs, Aldo Córdova‐Palomera, Dennis van der Meer, Jaroslav Rokicki, Torgeir Moberget, Tiril P. Gurholt, Unn K. Haukvik, Torill Ueland, Trine Vik Lagerberg, Ingrid Agartz, Ole A. Andreassen, Lars T. Westlye   +14 more
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Supplementary Table 1 from Agglomerative Epigenetic Aberrations Are a Common Event in Human Breast Cancer [PDF]

, 2023
Petr Novák, Taylor J. Jensen, Marc M. Oshiro, George S. Watts, Christina J. Kim, Bernard W. Futscher   +5 more
openalex   +1 more source

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

Nature, 2012
A. Biankin, N. Waddell, K. Kassahn, M. Gingras, L. Muthuswamy, A. Johns, David K. Miller, P. J. Wilson, A. Patch, Jianmin Wu, D. Chang, M. Cowley, B. Gardiner, Sarah Song, Ivon Harliwong, S. Idrisoglu, C. Nourse, Ehsan Nourbakhsh, Suzanne Manning, Shivangi Wani, M. Gongora, M. Pajic, C. Scarlett, A. Gill, Andreia V. Pinho, I. Rooman, M. Anderson, O. Holmes, C. Leonard, Darrin F. Taylor, S. Wood, Qinying Xu, K. Nones, J. Fink, Angelika N. Christ, T. Bruxner, N. Cloonan, G. Kolle, F. Newell, M. Pinese, R. S. Mead, J. Humphris, W. Kaplan, Marc D. Jones, E. Colvin, A. Nagrial, Emily S. Humphrey, A. Chou, V. Chin, L. Chantrill, A. Mawson, J. Samra, J. Kench, Jessica A. Lovell, R. Daly, N. Merrett, C. Toon, K. Epari, N. Nguyen, A. Barbour, N. Zeps, N. Kakkar, Fengmei Zhao, Y. Wu, Min Wang, D. Muzny, W. Fisher, F. Brunicardi, S. Hodges, J. Reid, J. Drummond, K. Chang, Yi Han, L. Lewis, H. Dinh, C. Buhay, T. Beck, Lee E. Timms, M. Sam, K. Begley, Andrew M. K. Brown, D. Pai, A. Panchal, Nicholas Buchner, R. D. Borja, R. Denroche, C. Yung, S. Serra, N. Onetto, D. Mukhopadhyay, M. Tsao, P. Shaw, G. Petersen, S. Gallinger, R. Hruban, A. Maitra, C. Iacobuzio-Donahue, R. Schulick, elliot k fishman, R. Morgan, R. Lawlor, P. Capelli, V. Corbo, M. Scardoni, G. Tortora, M. Tempero, K. Mann, N. Jenkins, P. A. Perez-Mancera, D. Adams, D. Largaespada, L. Wessels, A. Rust, Lincoln D. Stein, D. Tuveson, N. Copeland, E. Musgrove, A. Scarpa, J. Eshleman, T. Hudson, R. Sutherland, D. Wheeler, J. Pearson, J. McPherson, R. Gibbs, S. Grimmond   +125 more
semanticscholar   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Response to “Severe pernicious anemia with distinct cytogenetic and flow cytometric aberrations mimicking myelodysplastic syndrome” [PDF]

, 2012
Denise A. Wells, Michael R. Loken
openalex   +1 more source

Aberrations of DNA repair pathways in prostate cancer: a cornerstone of precision oncology [PDF]

, 2021
Stergios Boussios, Elie Rassy, Sidrah Shah, Evangelia Ioannidou, Matin Sheriff, Nicholas Pavlidis   +5 more
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Figure S2 from Novel Aberrations Uncovered in Barrett's Esophagus and Esophageal Adenocarcinoma Using Whole Transcriptome Sequencing

, 2023
Jesper L.V. Mååg, Oliver M. Fisher, Angelique Levert‐Mignon, Dominik C. Kaczorowski, Mélissa Thomas, Damian J. Hussey, David I. Watson, Antony Wettstein, Yuri V. Bobryshev, Melanie Edwards, Marcel E. Dinger, Reginald V. Lord   +11 more
openalex   +1 more source