Results 81 to 90 of about 873,697 (316)

Spatiotemporal local and abscopal cell death and immune responses to histotripsy focused ultrasound tumor ablation

Frontiers in Immunology, 2023
IntroductionHistotripsy is a novel focused ultrasound tumor ablation modality with potent immunostimulatory effects.MethodsTo measure the spatiotemporal kinetics of local andabscopal responses to histotripsy, C57BL/6 mice bearing bilateral flank B16 ...
Ashley L. Pepple, Ashley L. Pepple, Joey L. Guy, Joey L. Guy, Reliza McGinnis, Reliza McGinnis, Amy E. Felsted, Brian Song, Brian Song, Ryan Hubbard, Tejaswi Worlikar, Hannah Garavaglia, Joe Dib, Hannah Chao, Nicoleen Boyle, Nicoleen Boyle, Michal Olszewski, Zhen Xu, Anutosh Ganguly, Anutosh Ganguly, Clifford S. Cho, Clifford S. Cho   +21 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Theoretical basis of the diagonal scan method for determining the laser ablation threshold for femtosecond vortex pulses [PDF]

arXiv, 2018
In femtosecond laser micromachining, the ablation threshold is a key processing parameter that characterises the energy density required to cause ablation. Current techniques for measuring the ablation threshold such as the diameter regression and diagonal scan methods are based on the assumption of a Gaussian spatial profile, however no techniques ...
arxiv  

Momentum Transfer by Laser Ablation of Irregularly Shaped Space Debris [PDF]

, 2010
Proposals for ground-based laser remediation of space debris rely on the creation of appropriately directed ablation-driven impulses to either divert the fragment or drive it into an orbit with a perigee allowing atmospheric capture.
Libby, Stephen B., Liedahl, Duane A., Rubenchik, Alexander   +2 more
core   +2 more sources

Cooling or Warming the Esophagus to Reduce Esophageal Injury During Left Atrial Ablation in the Treatment of Atrial Fibrillation. [PDF]

, 2020
Ablation of the left atrium using either radiofrequency (RF) or cryothermal energy is an effective treatment for atrial fibrillation (AF) and is the most frequent type of cardiac ablation procedure performed. Although generally safe, collateral injury to
Arnold, M, Campos, B, Clark, B, Feher, M, Gallagher, MM, Guerra, JM, Hayat, J, Kulstad, E, Leung, LWM, MacGregor, J, Mazur, A, Metzl, M, Nazari, J, Santangeli, P, Sharkoski, T, Tschabrunn, C, Zagrodzky, J   +16 more
core   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Controlled Irradiative Formation of Penitentes

, 2006
Spike-shaped structures are produced by light-driven ablation in very different contexts. Penitentes 1-4 m high are common on Andean glaciers, where their formation changes glacier dynamics and hydrology.
A. J. Pedraza, C. Troll, Charles Berger, E. Gyorgy, J. J. Rhodes, L. Lliboutry, L. Lliboutry, M. D. Betterton, S. G. Foltyn, S. G. Warren, S. I. Dolgaev, V. M. Kotlyakov, Vance Bergeron   +12 more
core   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

T2-based temperature monitoring in bone marrow for MR-guided focused ultrasound. [PDF]

, 2016
BackgroundCurrent clinical protocols for MR-guided focused ultrasound (MRgFUS) treatment of osseous lesions, including painful bone metastases and osteoid osteomas, rely on measurement of the temperature change in adjacent muscle to estimate the ...
Bucknor, Matthew, Han, Misung, Krug, Roland, Ozhinsky, Eugene, Rieke, Viola   +4 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source