Results 131 to 140 of about 9,574,494 (334)

Nanosecond ablation of alumina with an ytterbium fibre-laser: experimental study, topography and damage evaluation [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Programa de Pós-Graduação em Ciência e Engenharia de Materiais, Florianópolis, 2014.Abstract : The use of advanced ceramics has been limited by the high machining costs, with grinding and ...
Gomes, Diego Ribas
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Ablation Resistance and Mechanisms of Non‐Equimolar (HfZrTaTiY)B ₂ Under Cyclic Oxyacetylene Flame Conditions

To explore ultra‐high temperature ceramics (UHTCs) with improved ablation resistance, a novel non‐equimolar high‐entropy diboride (HfZrTaTiY)B 2 and equimolar (HfZrTaTi)B 2 ...
Shaopu Liu, Xinchun Tian, Ziyan Wang, Zhuang Ma, Yinglu Li, Ling Liu, Yanbo Liu, Shizhen Zhu, Zhuohang Xie, Zhaowei Pan   +9 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Ablation mechanisms of bulk Nb4AlC3 ceramics at 1600–2200 °C in nitrogen plasma flame

Journal of Materials Research and Technology
MAX phase ceramics are promising thermal protection materials due to their excellent anti-oxidation and ablation resistance. This paper systematically investigates the ablation behaviors of Nb4AlC3 ceramics in nitrogen plasma flames at 1600–2200 °C.
Ye Yu, Hao Zhang, Zhen Teng, Yiwang Bao, Man Jiang, Longsheng Chu, Qingguo Feng, Chunfeng Hu   +7 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Preparation and ablation behavior of solid solution ceramic Ta0·2Zr0·8C–SiC matrix-modified C/C composites under high heat flux

Journal of Materials Research and Technology
To further enhance the ablation resistance of C/C composites, solid solution ceramic Ta0·2Zr0·8C was used to replace traditional ultra-high-temperature ceramic carbides for matrix modification of C/C composites.
Yuanming Zhou, Zhenxiao Tang, Ruizhi Liu, Zhe Zhou, Maozhong Yi, Ke Peng   +5 more
doaj   +1 more source

Magnetocardiographic demonstration of complex ventricular preexcitation resulting in ablation failure

, 2013
The Wolff-Parkinson-White (WPW) syndrome affects 1 to 3 persons per 1000. Catheter ablation (CA) is nowadays proposed as the preferred therapy (with success in more than 90% of cases) and ECG is the most used non-invasive method for classification and ...
Brisinda, Donatella, Sorbo, Anna Rita, Venuti, Angela, Fenici, Riccardo   +3 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source