Results 111 to 120 of about 187,327 (298)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Improving the Heat and Ablation Resistance of Silicone Rubber Composites by Incorporating Hollow Microspheres. [PDF]

Polymers (Basel), 2022
Tian J, Yan L, Zhang H, Zhou S, Xia S, Zou H.   +5 more
europepmc   +1 more source

Fabrication of (111)-Faced Single-Crystal Diamond Plates by Laser Nucleated Cleaving

, 2017
Single-crystal diamond plates with surfaces oriented in a (111) crystal plane are required for high-performance solid-state device platforms ranging from power electronics to quantum information processing architectures.
Bassett, Lee C., Grote, Richard R., Hopper, David A., Parks, Samuel M.   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Engineering C_f /ZrB₂ -SiC-Y₂ O₃ for Thermal Structures of Hypersonic Vehicles with Excellent Long-Term Ultrahigh Temperature Ablation Resistance. [PDF]

Adv Sci (Weinh), 2023
Chen B, Ni D, Bao W, Liao C, Luo W, Song E, Dong S.   +6 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Ablation mechanisms of bulk Nb4AlC3 ceramics at 1600–2200 °C in nitrogen plasma flame

Journal of Materials Research and Technology
MAX phase ceramics are promising thermal protection materials due to their excellent anti-oxidation and ablation resistance. This paper systematically investigates the ablation behaviors of Nb4AlC3 ceramics in nitrogen plasma flames at 1600–2200 °C.
Ye Yu, Hao Zhang, Zhen Teng, Yiwang Bao, Man Jiang, Longsheng Chu, Qingguo Feng, Chunfeng Hu   +7 more
doaj   +1 more source

Functionalized GO/Hydroxy-Terminated Polybutadiene Composites with High Anti-Migration and Ablation Resistance Performance. [PDF]

Polymers (Basel), 2022
Yin S, Lu Z, Bai H, Liu X, Li H, Hu Y.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Preparation and ablation behavior of solid solution ceramic Ta0·2Zr0·8C–SiC matrix-modified C/C composites under high heat flux

Journal of Materials Research and Technology
To further enhance the ablation resistance of C/C composites, solid solution ceramic Ta0·2Zr0·8C was used to replace traditional ultra-high-temperature ceramic carbides for matrix modification of C/C composites.
Yuanming Zhou, Zhenxiao Tang, Ruizhi Liu, Zhe Zhou, Maozhong Yi, Ke Peng   +5 more
doaj   +1 more source