Results 121 to 130 of about 3,414,706 (323)

Those of us with dyspraxia are frequently affected by academic ableism

The actions, inertia and discretion of individual academics can be a key driver of ableism – here’s what you and your institution can do to ...
Macklin, John
core  

From supercrip to techno supercrip

Current Issues in Sport Science
Participation in sport on all levels, physical activity, leisure and recreation is seen as important for disabled people but at the same time barriers are reported for disabled people.
Gregor Wolbring
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Dis/Entangling Disability, Mental Health, and the Cultural Politics of Care

Scandinavian Journal of Disability Research
This paper explores how understandings of care can be prefigured through engagements with concepts of ableism and sanism as productive and radical companions for (re)thinking care.
Katherine Runswick-Cole, Martina Smith, Sara Ryan, Patty Douglas   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Adverse Childhood Experiences of Disabled Children and Youth Resulting from Ableist Judgments and Disablist Treatments: A Scoping Review

Youth
Adverse childhood experiences (ACEs) are negative but preventable experiences within family and social environments. Originally focused on abuse and household dysfunction, ACE indicators now include many social factors, such as social determinants of ...
Gregor Wolbring, Parneet Dhindsa
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Neoliberal-Ableism and Inclusive Literacy Education, Paradox of

, 2022
Neoliberal-Ableism and Inclusive Literacy Education, Paradox ...
Ben Whitburn (13099872), Jennie Duke (19553275)   +1 more
core  

Lived Patron Experiences of Dysconscious Ableism in Public Library Spaces

In the Library with the Lead Pipe
This paper explores the lived experiences of disabled patrons in public library spaces, investigating how dysconscious ableism manifests in their daily interactions.
William N Myhill
doaj  

The Satire of Gerontophobic Ableism in Muriel Spark’s Memento Mori: A “Salutary Scar”

Études Écossaises
In recent years, the COVID‑19 pandemic highlighted the widespread reality of ableism and gerontophobia in many societies, as older and disabled people faced institutional violence.
Gabrielle Fath
doaj   +1 more source