Results 91 to 100 of about 149,179 (300)

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Structure and function of tetrameric hemoglobins and their mutants at a molecular and cellular level.

, 2011
The present Ph.D. thesis has focused on tetrameric hemoglobins (Hbs), both recombinant and natural, both from human origin and Antarctic fish, using a multidisciplinary approach based on spectroscopic, crystallographic and computational techniques.
Balsamo, Anna
core  

Structural study of hemoglobin Hazebrouck, β38(C4)Thr → Pro A new abnormal hemoglobin with instability and low oxygen affinity

, 1984
A new β-variant has been detected and structurally defined in a French male, with a life-long history of hemolytic anemia. This variant is moderately unstable and has a low oxygen affinity.
Blouquit, Y., J. Delanoe-Garin, Peduzzi, J., N. Arous, Y. Cayre, Delanoe-Garin, J., Y. Blouquit, C. Lacombe, Cayre, Y., F. Braconnier, Lacombe, C., Galacteros, F., F. Galacteros, J. Peduzzi, Arous, N., Braconnier, F.   +15 more
core   +1 more source

Innovations in Gastric Cancer Surgery During Early Minimally Invasive Era and Future Perspectives

Annals of Gastroenterological Surgery, EarlyView.
With continuing revelations in tumor biology and the emergence of artificial intelligence, new horizons for surgical innovation are opening. At the center of this transformative journey stands the innovative surgeon, driven by passion, guided by data, and steadfast in the commitment to patient safety and quality of life.
Reut El‐On, Young‐Woo Kim
wiley   +1 more source

Better 10‐Year Cerebrovascular Outcome After Transplant Than on Standard‐Care in Sickle Cell Anemia: DREPAGREFFE Trial

American Journal of Hematology, EarlyView.
ABSTRACT Management of cerebral vasculopathy in sickle cell anemia (SCA) includes standard‐care, that is, chronic transfusion (CT) or hydroxyurea, and hematopoietic cell transplantation (HCT). DREPAGREFFE‐1 (December 2010/June 2013), a French multicenter trial, was the first prospective trial comparing standard‐care to match sibling donor (MSD)‐HCT in ...
Francoise Bernaudin, Suzanne Verlhac, Elisabeth Ducros‐Miralles, Cécile Arnaud, Isabelle Genty, Marie Petras, Catherine Paillard, Gonzalo De Luna, Benoit Meunier, Isabelle Thuret, Annie Kamdem, Corinne Pondarré, Giovanna Cannas, Christelle Chantalat‐Auger, Nadia Firah, Sophie Pertuisel, Laure Joseph, Florence Missud, Mariane de Montalembert, Corinne Guitton, Claire Pluchart, Valentine Brousse, Monique Elmaleh, Vincent Gajdos, Emmanuella Leveillé, Ekaterina Belozertseva, Mabel Gaba, Catherine Poirot, Virginie Barraud‐Lange, Philippe Chadebech, France Pirenne, Myriam Bernaudin, Bénédicte Neven, Pierre Frange, Marie Angoso, Karima Yakouben, Bénédicte Bruno, Nathalie Dhédin, Jean‐Hugues Dalle, Regis Peffault Delatour, Camille Jung   +40 more
wiley   +1 more source

Research on the Screening Effect and Strategy of Fasting Plasma Glucose and Glycosylated Hemoglobin for Type 2 Diabetes and Prediabetes Mellitus [PDF]

Zhongguo quanke yixue
Background Currently, hospital physical examination centers or communities mainly use fasting plasma glucose and glycosylated hemoglobin as indicators to evaluate blood glucose levels. Previous studies explored the diagnostic value of detecting these two
ZHANG Lei, ZHANG Huanyu, CHEN Kaiyue, LI Xiaohong, GUO Ying
doaj   +1 more source

Multinomial regression model for predictors associated with abnormal hemoglobin levels (low and high) in first-trimester.

Multinomial regression model for predictors associated with abnormal hemoglobin levels (low and high) in first-trimester.
Hiba Hindi (18275405), Souad BelKebir (18275399), Mahmoud Hamdan (18275402), Basma Damiri (5123465), Haytham Abumohsen (18275396), Abeer Almusleh (18275414), Osama Yasin (18275417), Lubna Saudi (12447920), Rawnaq Abdaldaem (18275408), Baraa Bustami (18275411)   +9 more
core   +1 more source

Correction of Ineffective Erythropoiesis and Normalization of Iron Homeostasis After Exagamglogene Autotemcel in Transfusion‐Dependent β‐Thalassemia

American Journal of Hematology, EarlyView.
ABSTRACT Exagamglogene autotemcel (exa‐cel) is a one‐time, ex vivo, CRISPR‐Cas9 gene edited cell therapy approved for patients with transfusion dependent β‐thalassemia (TDT) aged 12–35 years. In a Phase 3 study (CLIMB THAL‐111), exa‐cel treatment resulted in reactivation of fetal hemoglobin and increases in total hemoglobin, leading to transfusion ...
Sujit Sheth, Selim Corbacioglu, Josu de la Fuente, Mattia Algeri, Joachim Rupprecht, Kevin H. M. Kuo, Ami J. Shah, Peter Lang, Hayley Merkeley, Ben Carpenter, Markus Y. Mapara, Robert I. Liem, Stephan Grupp, Yogi Chopra, Amanda M. Li, Janet L. Kwiatkowski, Melanie Kirby‐Allen, Maria Domenica Cappellini, Antonis Kattamis, Sakellarios Zairis, Tina Liu, William Hobbs, Haydar Frangoul, Franco Locatelli, Roland Meisel, on behalf of the CLIMB THAL‐111 and CLIMB‐131 Study Groups   +25 more
wiley   +1 more source

Hb Andrew-Minneapolis Variant in a Turkish Family

Turkish Journal of Hematology, 2023
Hamza Sümter, Soycan Mızrak, Serdar Ceylaner, Duran Canatan   +3 more
doaj   +1 more source

Detection of Hb variants and hemoglobinopathies in Indian population using HPLC: Report of 2600 cases

Indian Journal of Pathology and Microbiology, 2010
Background: Inherited abnormalities of hemoglobin synthesis include a myriad of disorders ranging from thalassemia syndromes to structurally abnormal hemoglobin variants. Identification of these disorders is immensely important epidemiologically and aid
Sachdev Ritesh, Dam Arpita, Tyagi Gaurav
doaj