Results 101 to 110 of about 149,179 (300)

A novel beta-globin variant: Hb Pocos de Caldas [beta 61(E5)Lys -> Gln]

, 2015
A novel hemoglobin (Hb) variant was found during a screening program for hemoglobinopathies in blood donors at the Hematology Center of the State University of Campinas, Campinas, Brazil. The carrier was a 30-year-old Caucasian woman of Native Indian and
Ogo, SH, Cesquini, M, Kimura, EM, Sonati, MF, Saad, STO, Jorge, SB, Albuquerque, DM, Fattori, A, Costa, FF   +8 more
core   +1 more source

Hemoglobin Kariya [α40 (C5) Lys → Glu]: a new hemoglobin variant with an increased oxygen affinity

, 1983
A new abnormal hemoglobin, Hb Kariya [α40 (C5) Lys → Glu], with an amino acid substitution at the α1β2 contact was discovered in a young Japanese man. This variant migrated to the anode faster than Hb A, being nearly the same as Hb I in electrophoretic ...
M. Seki, Harano, T., H. Fukui, A. Tsuneshige, Seki, M., S. Shibata, Yamada, H., K. Imai, T. Harano, Shibata, S., Ueda, S., K. Harano, H. Yamada, Fukui, H., Tsuneshige, A., Imai, K., S. Ueda, Harano, K.   +17 more
core   +1 more source

Therapeutic Silencing of Tmprss6 Reduces Iron‐Induced Inflammation and Prolongs Survival in MDS Mice

American Journal of Hematology, EarlyView.
ABSTRACT Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and an increased risk of progression to acute myeloid leukemia (AML). Despite advances in supportive and targeted therapies, disease‐modifying interventions remain limited.
Shahla Vilcassim, Nuttanan Pholngam, Rattanawan Thubthed, Tiwaporn Nualkaew, Saovaros Svasti, Pornthip Chaichompoo, Kai Kysenius, Peter J. Crouch, Sibylle Dames, Mona Eisermann, Alberto Martinez, Ute Schaeper, Jim Vadolas, George Grigoriadis   +13 more
wiley   +1 more source

First Observation of Hemoglobin San Diego, a High Oxygen Affinity Hemoglobin Variant, in Turkey

Turkish Journal of Hematology, 2017
Ebru Yılmaz Keskin, Ali Fettah, Ana Catarina Oliveira, Şule Toprak, Andreia Lopes, Celeste Bento   +5 more
doaj   +1 more source

Relationship of function and higher order structure of abnormal hemoglobin.

, 2003
本研究ではヘモグロビン(Hb)の持つアロステリー(協同性)と蛋白質の立体構造変化との関連を知る目的で、主に機能異常を呈する異常血色素を用いてその機能と構造ついて調べた。蛋白質の構造変化は主に紫外円二色性(UVCD)と紫外共鳴ラマン分光法(UVRR)により追求した。研究成果は次の3つにまとめられる。 1.UVCDによるヘモグロビン四次構造変化に関する研究:Deoxy型のみにみられる287nmの負のCDバンドが何に由来するか、サブユニット接触面に変異を有する異常血色素を用いて調べた(業績1、2)。 2 ...
長井, 雅子, 49415, 60019578
core   +1 more source

Therapeutic Outcomes in VEXAS Syndrome: A Multicenter Comparative Cohort of Allogeneic Hematopoietic Stem Cell Transplantation and Hypomethylating Agents

American Journal of Hematology, EarlyView.
Key findings of therapeutic outcomes from a multi‐center cohort of VEXAS patients. ABSTRACT Hypomethylating agents (HMA) and allogeneic hematopoietic stem cell transplantation (alloHSCT) have both demonstrated remissions in VEXAS; however, comparative data is lacking.
Saubia Fathima, Margaret Mei‐Kay Wong, Jesus Gonzalez‐Lugo, Susan M. Geyer, Ali Alsugair, Maria Sirenko, Kimberly J. Langer, Terra L. Lasho, Christy Finke, Jun Choi, Maher Abdul‐Hay, Gary Ho, Mark R. Litzow, Aasiya Matin, Urshila Durani, Mehrdad Hefazi, William J. Hogan, Mithun V. Shah, Aref Al‐Kali, Kebede H. Begna, Naseema Gangat, Antoine N. Saliba, Ronald S. Go, Tariq Kewan, Gabriel Bartoo, Jade Kutzke, Kristen McCullough, Kenneth J. Warrington, Megan Sullivan, Kaaren K. Reichard, Horatiu Olteanu, Hemant Murthy, Talha Badar, Yael Kusne, Jeanne Palmer, Saurabh Chhabra, Nathan Punwani, Mary Riwes, Joseph P. McGuirk, Elizabeth F. Krakow, Amelia Langston, Taxiarchis Kourelis, David Dingli, James Foran, Matthew J. Koster, Mrinal M. Patnaik, David B. Beck, Hassan B. Alkhateeb, Abhishek A. Mangaonkar   +48 more
wiley   +1 more source

Atypical Clinical Course of Griscelli Syndrome Type 2 With Primarily Neurologic Presentation and Adult‐Onset in a 46‐Year‐Old Male

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Griscelli Syndrome Type 2 (GS2) is a rare autosomal recessive disorder caused by pathogenic mutations in the RAB27A gene. Typically, it is characterized by cutaneous hypopigmentation, immunodeficiency, with or without neurological abnormalities secondary to hemophagocytic lymphohistiocytosis (HLH). Without treatment, GS2 often results in fatal
Dzhoy Papingi, Michael Kutsche, Helena Lichtenfeld, Fanny Kortüm, Angela Abicht, Laura Herrmann, Theresia Herget   +6 more
wiley   +1 more source

Phenotypic profiling of pristane‐induced mimicking human systemic lupus erythematosus in Macaca fascicularis

Animal Models and Experimental Medicine, EarlyView.
Pristane (5 mL/kg) induced a robust systemic lupus erythematosus (SLE)‐like phenotype in Macaca fascicularis, marked by elevated antinuclear antibody (ANA) levels and systemic clinical, hematological, and biochemical changes. This model closely reflects human SLE and provides a translational platform for disease studies and therapeutic evaluation ...
Jonny Jonny, Soetojo Wirjopranoto, Chairul A. Nidom, I Ketut Sudiana, Terawan A. Putranto, Elisa D. Pratiwi, Tiza W. Mawaddah, Astria N. Nidom, Reviany V. Nidom, Setyarina Indrasari, Irma Y. Rosytania, Hiqmah Y. Yana, Sanindita Kusumastuti   +12 more
wiley   +1 more source

Genetic prediction of blood cell reactivity and its potential causal influence on bone continuity and density disorders

Animal Models and Experimental Medicine, EarlyView.
We applied Mendelian randomization to explore causal links between blood cell traits and skeletal disorders. Using genetic instruments from large‐scale summary statistics, we assessed effects on bone continuity, density, and structural integrity. Sensitivity and reverse analyses confirmed robust associations, highlighting potential shared biological ...
Zhiqin Deng, Zhe Zhao, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Zhengyang Lin, Zhenhan Deng, Wencui Li   +8 more
wiley   +1 more source

Prevalence Of Common Hemoglobinopathies in Gujarat: An Analysis of a Large Population Screening Program

National Journal of Community Medicine, 2012
Objectives: To determine prevalence and geographical distribution of ß-thalassemia trait and sickle cell trait in Gujarat Methods: The present study includes 3, 17,539 persons who were screened for hemoglobinopathies from September 2004 to November ...
Ashwin P Patel , Madhuben R Naik , Nilam M Shah , Narmadeshwar P Sharma , Prakash H Parmar   +4 more
doaj