Results 201 to 210 of about 307,093 (281)

Chest pain management in acute coronary syndrome and chronic stable angina with diluted xylocaine injections. [PDF]

Bioinformation
Jain S, Jain R, Jain AD.
europepmc   +1 more source

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

Joint position statement on atrial shunts (persistent [patent] foramen ovale and atrial septal defects) and diving: 2025 update. South Pacific Underwater Medicine Society (SPUMS) and the United Kingdom Diving Medical Committee (UKDMC). [PDF]

Diving Hyperb Med
Smart D, Wilmshurst P, Banham N, Turner M, Mitchell SJ.   +4 more
europepmc   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Policy and legal perspectives on the traditional Chinese medicine varietal protection system (TCMVPS): reform or abolition? [PDF]

Front Pharmacol
Wang Y, Sun K, Hua D.
europepmc   +1 more source

The Safety Appliance Act and the FELA: A Plea for Clarification [PDF]

, 1953
Anderson, Kenneth M., Louisell, David W.
core   +1 more source

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

Buffered Cortisol Response to Stress in Patients With Epilepsy and Its Association With Memory and Quality of Life. [PDF]

Neurology
Catalán-Aguilar J, González-Bono E, Villanueva V, Hampel KG, Lozano-García A, Hidalgo V, Salvador A, Tormos-Pons P, Cano-López I.   +8 more
europepmc   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Tracing the Uncharted African Diaspora in Southern Brazil: The Genetic Legacies of Resistance in Two <i>Quilombos</i> from Paraná. [PDF]

Genes (Basel)
Joerin-Luque IA, Baldon Blaczyk I, Ianzen Dos Santos P, Guimarães Alves AC, Sukow NM, Malanczyn de Oliveira AC, Farias de Cristo T, Rodrigues do Amaral Bispo A, Gros AF, Santos Saatkamp ML, Dobis Barros V, Gehlen Tessaro J, da Silveira Costa ME, Leonardo Garcia L, Dall Oglio Bucco I, de Moura Bones DR, Cupertino SE, Boslooper Gonçalves L, Leandro Martins A, da Silva Guizelin G, de Paula AI, Vieira Gusmão Lopes C, Beltrame MH.   +22 more
europepmc   +1 more source