Results 41 to 50 of about 308,321 (299)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Content of pardon and some doubts regarding its implementation [PDF]
Anali Pravnog Fakulteta u Beogradu, 2017 The granting of a pardon to a person who has committed a criminal offence or who has been convicted of a criminal offence is an act of mercy vested in heads of the President of Republic. According to the Criminal Code, pardon shall release a specifically
Vuković Igor, Bajović Vanja
doaj +1 more source
A Rapid Assessment of Bonded Labour in Hazardous Industries in Pakistan: Glass Bangle-Making, Tanneries, and Construction [PDF]
, 2004 This working paper is one of a series of Rapid Assessments of bonded labor in Pakistan, each of which examines a different economic sector. The aim of these studies is to inform the implementation of the Government of Pakistan’s National Policy and Plan ...
InFocus Programme on Promoting the Declaration on Fundamental Principles and Rights at Work +1 more
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Drilled Choreographies: Interventions on Preparing for the Active Shooter
Conversations Across the Field of Dance StudiesIn the United States, safety preparation in the form of active shooter trainings are quotidian practices performed in nearly all K-12 public school systems. This paper works to understand how active shooter trainings in the U.S.
Shannon Woods
doaj +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Identity Documents and Gender Identity: Towards Inclusive Practices
Perspective PoliticeIn a world increasingly focused on inclusivity, addressing the challenges faced by gender nonconforming and transgender individuals is crucial. Identity documents are meant to represent us, but the current approaches of administrative systems in ...
Elisabeth-Gabrielle SATALAN
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source