Results 51 to 60 of about 77,071 (250)

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Drilled Choreographies: Interventions on Preparing for the Active Shooter

Conversations Across the Field of Dance Studies
In the United States, safety preparation in the form of active shooter trainings are quotidian practices performed in nearly all K-12 public school systems. This paper works to understand how active shooter trainings in the U.S.
Shannon Woods
doaj   +2 more sources

Against Abolition

Feminist Philosophy Quarterly, 2019
Analytic metaphysics of gender has taken an ameliorative turn towards ethical and political questions regarding what our concept of gender ought to be, and how gendered society should be structured.
Matthew J Cull
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Identity Documents and Gender Identity: Towards Inclusive Practices

Perspective Politice
In a world increasingly focused on inclusivity, addressing the challenges faced by gender nonconforming and transgender individuals is crucial. Identity documents are meant to represent us, but the current approaches of administrative systems in ...
Elisabeth-Gabrielle SATALAN
doaj   +1 more source

L’abolition des droits féodaux en France

Cahiers d’histoire, 2005
Cette courte synthèse a pour objet de retracer succinctement les trois grandes étapes qui ont conduit à l’abolition définitive et sans indemnité des droits féodaux et seigneuriaux le 17 juillet 1793.
Jean-Jacques Clere
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Compilation of presentations abstracts : International Conference on Penal Abolition

, 1987
Collection of abstracts from the 1987 International Conference on Penal Abolition (ICOPA III). Table of Contents: Les autochtones et la justice au Quebec : le cas des Inuit du Nouveau-Quebec / Mylene Jaccoud -- The outcome of colonisation on Native ...

core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Penal Abolition and the State: Colonial, Racial and Gender Violences

, 2017
The present issue of Contemporary Justice Review constitutes the first of three issues on the topic of penal abolition, assembled by us in an effort to bring the history and current character of penal abolition research to readers both familiar with and ...
Coyle, Michael J., Schept, Judah, Judah Schept, Michael J. Coyle   +3 more
core   +1 more source