Results 71 to 80 of about 308,321 (299)
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
'The live dynamic whole of feeling and behavior': capital punishment and the politics of emotion, 1945–1957 [PDF]
, 2012 No description ...
Abrams +36 more
core +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Global Zero: The new old agenda [PDF]
, 2009 The project of abolishing all nuclear weapons has been given fresh impetus but the old questions remain. Having regard to the manifold problems of definition and verification, is 'Global Zero' realistic in a world in which proliferation seems more likely
Smith, Ron C.
core +1 more source
Abolishing user fees for children and pregnant women trebled uptake of malaria-related interventions in Kangaba, Mali. [PDF]
, 2011 Malaria is the most common cause of morbidity and mortality in children under 5 in Mali. Health centres provide primary care, including malaria treatment, under a system of cost recovery.
Audibert +15 more
core +2 more sources
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
“That Sottish and Selfish principle”: Cugoano on Self-Interest, Imagination, and Moral Wrongdoing
Journal of Modern PhilosophyThe following paper analyzes Ottobah Cugoano’s argument against the type of moral wrongdoing of those who participated in the practices of the transatlantic slave trade and of enslavement. I will argue that Cugoano describes moral wrongdoing in a general
Aminah Hasan-Birdwell
doaj +2 more sources
Real Estate Prices and the Importance of Bequest Taxation [PDF]
In the context of a general equilibrium model with overlapping generations and intergenerational altruism we show that, ceteris paribus, a decrease in taxes on inter vivos donations and bequests brings about an increase in real estate prices. This result
Filippo Taddei, Giorgio Bellettini
core
Logos I - Philosophy and the Nature of Morality: The Abolition of Man, C.S. Lewis [PDF]
, 2018 C.S. Lewis’ objective stance on ethics is argued to be superior to the moral sentimentalism of David Hume, because if there is not agreement on what constitutes moral action, then there is no basis for argument over the existence of moral ...
Steiner, Lucie
core +1 more source
A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source