Results 81 to 90 of about 77,071 (250)
Pre-Packaged Policing: Commodifying Bundled Surveillance and Lessons from Abolition
Surveillance & SocietyThis paper examines pre-packaged policing: the outsourcing of complex policing functions to technology companies as parcelled socio-technical services, offered as a subscription to governments who do not need technical expertise. These varied commodities
Yung Au
doaj +1 more source
Impact of the abolition of EU Milk quotas on Agriculture in the UK [PDF]
In recent years the CAP has undergone significant reforms, but the dairy sector has largely avoided wholesale changes. The sector, however, is now faced with a significant effort by the Commission to instigate reform. In this study the FAPRI-UK modelling
Patton, Myles +6 more
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IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
, 2017 Three themes have characterized death penalty abolition throughout the Western world: a sustained period of de facto abolition; an understanding of those in government that the death penalty implicates human rights; and a willingness of those in ...
Barry, Kevin M.
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ACMEIn this piece, I suggest that a critical geography must be curious about how we can do geography differently in order to collectively work towards a more inclusive and just discipline.
Malene Jacobsen
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FEBS Open Bio, EarlyView.The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao +23 more
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes +75 more
wiley +1 more source
Conformational Switching of Proteins on Material Surfaces Enabled by Peptide‐Oriented Adsorption
Advanced Functional Materials, EarlyView.Responsive biointerfaces could be achieved using conformationally responsive proteins; however, their interconversion can be lost upon surface adsorption. Herein, we demonstrate that the incorporation a Au binding peptide into calmodulin allows for binding control on Au wherein the protein retains conformational switching. This capability was confirmed
Sakthirupini Ramamurthy +7 more
wiley +1 more source
Capital punishment: a review and critique of abolition strategies
, 2008 The objective of this chapter is to review and critique the various strategies adopted in pursuit of the abolition of capital punishment and to proffer a model that is both evidence based and holistic in preparing for abolition and its aftermath ...
Kandelia, S. +2 more
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