Results 81 to 90 of about 61,325 (295)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Fossil Fuel Abolition: Legal and Social Issues [PDF]
, 2016 This Article will examine the practical, ethical, legal, and socio-political implications of fossil fuel abolition. First, the Article will consider the practical, ethical, and legal arguments in favor of fossil fuel abolition.
Coplan, Karl S.
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source
“That Sottish and Selfish principle”: Cugoano on Self-Interest, Imagination, and Moral Wrongdoing
Journal of Modern PhilosophyThe following paper analyzes Ottobah Cugoano’s argument against the type of moral wrongdoing of those who participated in the practices of the transatlantic slave trade and of enslavement. I will argue that Cugoano describes moral wrongdoing in a general
Aminah Hasan-Birdwell
doaj +2 more sources
Evangélisme et politique dans la jeune République
Transatlantica, 2006 Since the emergence of ethno‑historical studies in the 1960s and 70s suggesting a link between religious affiliation and electoral behavior during the early republic and the antebellum period, historiographies of religious and political culture have both
Lucia Bergamasco
doaj +1 more source
Death Penalty Abolition Week [PDF]
Monday, March 24 - Thursday, March 27, 2025 The Exoneration Justice Clinic and the Klau Institute for Civil and Human Rights are excited to invite you to the inaugural Death Penalty Abolition Week at Notre Dame Law School, which will take place from ...
Black Law Students Association +5 more
core +1 more source
Slavery, Abolition, and Emancipation [PDF]
, 2016 Les pages du site "Slavery, Abolition, and Emancipation" renvoient vers de nombreuses ressources sur l'étude de l'esclavage, de son abolition et de son émancipation.
Ginouvès, Véronique
core
Penal Abolition and the State: Colonial, Racial and Gender Violences [PDF]
, 2017 The present issue of Contemporary Justice Review constitutes the first of three issues on the topic of penal abolition, assembled by us in an effort to bring the history and current character of penal abolition research to readers both familiar with and ...
Coyle, Michael J. +3 more
core +1 more source