Results 91 to 100 of about 158,097 (358)

Effect of aging temperature on microstructure and properties of maraging steel for ultra-low temperature

Journal of Materials Research and Technology
An 18Ni(200) maraging steel ingot was prepared using vacuum smelting, and after undergoing forging and two solution treatments at 1000 °C + 800 °C, the effect of aging treatment at 350–600 °C on the evolution of the microstructure and mechanical ...
Jikang Hu, Yucheng Zhou, Litao Yin, Haoqiang Zhang, Zhou Li, Liujie Xu   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Investigation of the Friction and Wear Behavior of Cr-Mo-V Steel with Different Surface Treatment Processes

Lubricants
Hot work die steel is an alloy steel with good high-temperature performance, which is widely used in mechanical manufacturing, aerospace, and other fields.
Wei Zhang, Jian Zhang, Shizhong Wei, Liuliang Chen, Wei Zhang, Zhenhuan Sun, Chong Chen, Feng Mao, Xiaodong Wang, Caihong Dou, Cheng Zhang   +10 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Abrasion-corrosion of cast CoCrMo in simulated hip joint environments

, 2009
Metal-on-metal (MoM) hip joint replacements have been increasingly used for younger and more active patients in recent years due to their improved wear performance compared to conventional metal-on-polymer bearings.
Sun, Dan
core  

Corrosion and wear resistant electrodeposited composite coatings

, 2005
Composite electroplating is a method allowing to co-deposit fine particles of metallic or non metallic compounds into the plated layers in order to improve the surface properties.
Kouloumbi, N, Kouloumbi, Niki, Gajo, M, Lekka, M, Bonora, Pier Luigi, Bonora, PL, Gajo, Mauro, LEKKA, Maria   +7 more
core   +1 more source

Contribuição ao estudo da retificação abrasiva de materiais cerâmicos Introduction to abrasive grinding of ceramics

Cerâmica, 2006
Uma das principais limitações relacionadas ao processo de retificação de cerâmica é a confiabilidade do material devido aos defeitos introduzidos no processamento.
H. Fujita, E. C. Bianchi, P. R. de Aguiar, L. E. de A. Sanchez, C. E. da Silva Jr.   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Properties of Normal and Recycled Brick Aggregates for Production of Medium Range (25–30 MPa) Structural Strength Concrete

Buildings, 2018
This study compares the properties of normal and recycled brick aggregates to produce a medium range (25–30 MPa) compressive strength of structural grade concrete.
Suvash Chandra Paul, Adewumi John Babafemi, Vivi Anggraini, Md. Minhaz Rahman   +3 more
doaj   +1 more source