Results 71 to 80 of about 206,191 (361)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Journal of Materials Research and TechnologyAn 18Ni(200) maraging steel ingot was prepared using vacuum smelting, and after undergoing forging and two solution treatments at 1000 °C + 800 °C, the effect of aging treatment at 350–600 °C on the evolution of the microstructure and mechanical ...
Jikang Hu +5 more
doaj +1 more source
Mass Distribution of Particulate Matter Produced During Abrasion af Asphalt Mixtures in Laboratory
Communications, 2016 Non-exhaust emissions of particulate matter from road traffic can come from abrasion of vehicle parts (tyres, brake linings, clutch and bodywork) or from pavement surface abrasion and also from resuspension of dust. A differentiation between PM emissions
Dasa Fullova +3 more
doaj +1 more source
Abrasion and resistant discharge valve developed [PDF]
, 1969 Discharge valve capable of withstanding intense radiation and high abrasion was developed for use in a fluidized bed reactor. The valve which employs a replaceable Teflon seal, has only one moving part and is designed for remote assembly and ...
Gottwald, W. L.
core +1 more source
Multidecadal (1960–2011) shoreline changes in Isbjørnhamna (Hornsund, Svalbard) [PDF]
, 2015 A section of a gravel-dominated coast in Isbjørnhamna (Hornsund, Svalbard) was analysed to calculate the rate of shoreline changes and explain processes controlling coastal zone development over last 50 years.
Błaszczyk, Małgorzata +9 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Wear of human teeth: a tribological perspective [PDF]
, 2005 The four main types of wear in teeth are attrition (enamel-on-enamel contact), abrasion (wear due to abrasive particles in food or toothpaste), abfraction (cracking in enamel and subsequent material loss), and erosion (chemical decomposition of the tooth)
Amaechi B. T. +18 more
core +2 more sources
Dual drug-loaded coaxial nanofibers for the treatment of corneal abrasion [PDF]
, 2020 Essam A. Tawfik +2 more
openalex +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source