Results 61 to 70 of about 206,191 (361)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Building a composition-microstructure-performance model for C–V–Cr–Mo wear-resistant steel via the thermodynamic calculations and machine learning synergy

Journal of Materials Research and Technology
To better understand the complex relationships between composition, microstructure, and performance in C–V–Cr–Mo wear-resistant steel, and to facilitate the rapid and efficient development of high-alloy steels for extreme working conditions, this study ...
Shuaiwu Tong, Shuaijun Zhang, Chong Chen, Tao Jiang, Peng Li, Shizhong Wei   +5 more
doaj   +1 more source

Improvement and In-Situ Application of an Evaluation Method of Ballasted-Track Condition Using Digital 2-D Image Analysis

Applied Sciences, 2020
The advancement in digital image analysis methods has led to the development of various techniques, i.e., quantification of ballast gravel abrasion. In this study, the recognition rate of gravel aggregates has been significantly increased by improving ...
Bongsik Park, Yeong-Tae Choi, Hyunmin Kim   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Review of Research on Hydraulic Mechanical Abrasion

Renmin Zhujiang, 2021
In the working process of hydraulic machinery,it is inevitable to suffer from the abrasion of fluid containing impurities.This paper introduces abrasion systematically and comprehensively from the following five aspects:the formation mechanism and ...
LI Xiaochao, XIE Weiwei, ZHANG Hao, QIN Rong, WANG Xiaoli   +4 more
doaj  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Multiphase-based predictive framework construction of abrasive wear performance in C–V–Cr–Mo alloys

Journal of Materials Research and Technology
Abrasive wear persists as the dominant failure mechanism in crushing equipment, driving the demand for predictive models to guide wear-resistant alloy design and equipment lifespan assessment.
Tao Jiang, Xuke Yao, Mengmeng Ma, Hua Yu, Junjie Sun, Yuanguang Liu, Xuezhong Hu, Chong Chen, Chunhua Lei, Xiaodong Wang   +9 more
doaj   +1 more source

Some remarks on particle size effects on the abrasion of a range of Fe based alloys [PDF]

, 2010
The low-stress three body abrasion behaviour of a range of steels was investigated. The tests were carried out in a rubber wheel tester (according to ASTM G65-94, reapproved in 2000) at room temperature.
Almeraya-Calderon, F., Cabral-Miramontes, J.A., Chacon-Nava, J. G., Martinez-Villafañe, A., Stack, M.M.   +4 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Solid particle erosion and viscoelastic properties of thermoplastic polyurethanes [PDF]

, 2015
The wear resistance of several thermoplastic polyurethanes (TPUs) having different chemical nature and micronscale arrangement of the hard and soft segments has been investigated by means of erosion and abrasion tests.
ACIERNO, DOMENICO, ARENA, GAETANO, FILIPPONE, GIOVANNI, Friedrich, K., Padenko, E., Russo, P., Wagner, J.   +6 more
core   +3 more sources