Results 61 to 70 of about 158,097 (358)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Abrasiveness and whitening effect of charcoal-containing whitening toothpastes in permanent teeth.

open access: yesDental Research Journal, 2021
Background: Charcoal toothpastes can whiten teeth through abrasion. The purpose of this study was to determine the level of whitening and abrasiveness of charcoal toothpastes in permanent teeth. Materials and Methods: In this in vitro study, 30 premolars
Masoud Fallahinejad Ghajari   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Effect of Carbon Content on Abrasive Impact Wear Behavior of Cr-Si-Mn Low Alloy Wear Resistant Cast Steels

open access: yesFrontiers in Materials, 2019
The effects of carbon contents on microstructure evolution and mechanical properties, including hardness, impact toughness and abrasive impact wear resistance behavior, were investigated for Cr-Si-Mn low alloy cast steels.
Xiaodong Wang   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Metodologia para avaliação do desgaste em ferramentas simétricas de mobilização do solo Methodology for assessment of wear rate in symmetrical soil-engaging tools

open access: yesRevista Brasileira de Engenharia Agrícola e Ambiental, 2009
A correta avaliação e previsão do tempo de vida útil dos mecanismos que atuam no rompimento do solo, são importantes na análise de equipamentos. O desgaste deste tipo de ferramenta (ponteiras sulcadoras de semeadoras, de escarificadores e de subsoladores)
Antônio L. T. Machado   +5 more
doaj   +1 more source

Effect of Vibration on the Porosity and Strength of Instant Drink Granules

open access: yesТехника и технология пищевых производств, 2022
Instant food products are extremely popular, and food industry knows numerous ways and methods of their production. To remain competitive, an instant drink production process should be efficient and flawless.
Anatoliy M. Popov   +5 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Thickness of softened human enamel removed by toothbrush abrasion: an in vitro study [PDF]

open access: yes, 2010
The aim of the study was to assess the thickness of softened enamel removed by toothbrushing. Human enamel specimens were indented with a Knoop diamond. Softening was performed with citric acid or orange juice.
Lussi, A, Voronets, J
core   +1 more source

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