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The abscopal effect and chronic lymphocytic leukemia
The American Journal of Medicine, 1995T he remote effect of irradiation on malignancies outside the radiation field is described in the older literature, however, in recent years there has been a paucity of clinical reports on this phenomenon. This case report describes a patient with chronic lymphocytic leukemia who had dramatic improvement of his splenomegaly and lymphocytosis after ...
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Systematic review of case reports on the abscopal effect
Current Problems in Cancer, 2016Radiation therapy is a highly effective local treatment for cancer. However, sporadic events of tumor regression in unirradiated fields, known as abscopal effect, have been observed for decades. This abscopal effect has more recently been postulated to be a result of antitumor immune response induced by radiation therapy.
Yazan, Abuodeh +2 more
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ABSCOPAL EFFECTS OF LOCALIZED IRRADIATION BY ACCELERATOR BEAMS*
Annals of the New York Academy of Sciences, 1964The existence of abscopal effects of radiation, those in organs at a distance from the irradiated volume in mammals, was investigated. Swiss Albino mice were irradiated over portions of the abdomen with 20 Mev deuterons. The mean thyraus and spleen weights in animals receiving abdominal irradiation were markedly depressed in comparison to controls and ...
C R, JANSEN +3 more
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The abscopal effect: Implications for drug discovery in autoimmunity
Autoimmunity Reviews, 2023The emergence of novel targeted therapies and the tools that increase the stability and delivery of drugs have greatly improved treatment outcomes in autoimmune diseases (ADs). Recently-developed strategies deplete specific deleterious T- and B-cell subsets, interrupt receptor-ligand interactions, and/or inhibit the secretion or activity of ...
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A macrophage-activated abscopal effect
Nature Cancer, 2022Christopher A. Barker, Nadeem Riaz
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The immune mechanisms of abscopal effect in radiation therapy
Current Problems in Cancer, 2016Radiation therapy (RT) is a cornerstone in oncologic management and is employed in various curative and palliative scenarios for local-regional control. RT is thought to locally control tumor cells by direct physical DNA damage or indirect insults from reactive oxygen species.
G Daniel, Grass +2 more
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Abscopal Effects and Immunomodulation in Skin Cancer Therapy
American Journal of Clinical DermatologyRadiation therapy (RT) is a crucial modality in cancer treatment, functioning through direct DNA damage and immune stimulation. However, RT's effects extend beyond targeted cells, influencing neighboring cells through the bystander effect (ByE) and distant sites via the abscopal effect (AbE).
William J. Nahm +2 more
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[Abscopal effect in the treatment of malignant melanoma].
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2016The clearance of non-irradiated tumors after localized radiation therapy is known as the abscopal effect.In the present case report we initiated a combined therapeutic approach based on sequential administration of ipilimumab plus temozolomide in combination with radiotherapy.
C, Thallinger +3 more
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The Abscopal Effect: A Review of Pre-Clinical and Clinical Advances
International Journal of Molecular Sciences, 2021Yang Shen +2 more
exaly
Abscopal Effect on Hepatocellular Carcinoma
The American Journal of Gastroenterology, 2008Mitsuru Nakanishi +2 more
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