Results 131 to 140 of about 2,372,972 (378)

Déjà vu and the entorhinal cortex: dissociating recollective from familiarity disruptions in a single case patient [PDF]

, 2018
Past research has demonstrated a relationship between déjà vu and the entorhinal cortex in patients with wider medial temporal lobe damage. The aim of the present research was to investigate this crucial link in a patient (MR) with a selective lesion to ...
Brandt, K. R., Conway, M. A., James, A., von Oertzen, T. J.   +3 more
core   +2 more sources

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Childhood Absence Epilepsy

Childhood absence epilepsy (CAE) is a common epilepsy syndrome characterized by absence seizures affecting young children and representing 18% of all diagnosed cases of epilepsy in school-age children. Absence seizures are classically very frequent during the day and each seizure lasts a short time, from about 10 to 20 seconds, it ends abruptly, and ...
Vetri, Luigi, Costanza, Carola, Siciliano, Margherita, Precenzano, Francesco, Gallai, Beatrice, Carotenuto, Marco   +5 more
openaire   +4 more sources

Cortical Tonic Inhibition Gates the Expression of Spike-and-Wave Discharges Associated with Absence Epilepsy

Journal of Integrative Neuroscience
Objective: Absence seizures result from aberrant thalamocortical processing that confers synchronous, bilateral spike-and-wave discharges (SWDs) and behavioral arrest.
Kile P. Mangan, Aaron B. Nelson, Steven Petrou, Chiara Cirelli, Mathew V. Jones   +4 more
doaj   +1 more source

Enhancement of Calcium Ion Permeation via Resonant Coupling of Ion and Terahertz Waves in Voltage Gated Calcium Channels

Advanced Science, EarlyView.
We introduce a novel, ion‐targeted strategy to enhance calcium permeation in voltage gated calcium channels. By directly driving the ions’ coherent collective motion via resonant coupling with a 1.65 THz field, we lower the inter‐site energy barrier, inducing a statistically significant enhancement of ion influx.
Zihao Zhang, Yuankun Sun, Xinqiao Zhou, Sunchao Huang, Shengpeng Yang, Shaomeng Wang, Yubin Gong   +6 more
wiley   +1 more source

Interictal focal epileptic discharges in a pediatric patient with absence status epilepsy: a mimicker of focal epilepsy

Epilepsy & Behavior Reports
Absence status epilepsy (ASE) is a rare generalized epilepsy that usually manifests in adolescence or adulthood, although pediatric-onset cases have also been described.
Kento Ohta, Go Yoshino, Masami Togawa, Tohru Okanishi, Yoshihiro Maegaki   +4 more
doaj   +1 more source

Osmotic Edema Rapidly Increases Neuronal Excitability Through Activation of NMDA Receptor-Dependent Slow Inward Currents in Juvenile and Adult Hippocampus. [PDF]

, 2015
Cellular edema (cell swelling) is a principal component of numerous brain disorders including ischemia, cortical spreading depression, hyponatremia, and epilepsy.
Binder, Devin K, Davila, David, Fiacco, Todd A, Lauderdale, Kelli, Murphy, Thomas, Tung, Tina   +5 more
core   +3 more sources

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Absence Epilepsy with Fast Rhythmic Atypical EEG

Pediatric Neurology Briefs, 2001
The medical files of 31 patients with absence epilepsy (AE) were reviewed at La Timone University Hospital, and Henri Gastaut/Saint Paul Hospital, Marseilles, France.
J Gordon Millichap
doaj   +1 more source

Effect of stage 2 kindling on local cerebral blood flow rates in rats with genetic absence epilepsy [PDF]

, 2008
Nihan Çarçak, Arielle Ferrandon, Estelle Koning, Rezzan Aker, Osman Özdemir, Filiz Onat, Astrid Nehlig   +6 more
openalex   +1 more source