Results 71 to 80 of about 2,104,112 (314)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Antiretroviral therapy and early mortality in South Africa
Bulletin of the World Health OrganizationOBJECTIVE: To describe province-wide outcomes and temporal trends of the Western Cape Province antiretroviral treatment (ART) programme 5 years since inception, and to demonstrate the utility of the WHO monitoring system for ART.
Andrew Boulle +10 more
doaj +1 more source
Идея Абсолюта в эстетических взглядах и музыке Карела Гуйвартса
Вестник музыкальной науки, 2018 Статья посвящена изучению эстетических взглядов бельгийского композитора Карела Гуйвартса (1923-1993). Наряду с Штокхаузеном, Булезом и другими, он стоял у истоков сериальной и электронной музыки. Взгляды композитора дают представление о духовных основах
Окунева, Екатерина Гурьевна
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Absolute, true and mathematical time in Newton’s Principia [PDF]
, 2013 I discuss the three distinctions “absolute and relative”, “true and apparent”, and “mathematical and common”, for the specific case of time in Newton’s Principia. I argue that all three distinctions are needed for the project of the Principia and can be
Brading, Katherine
core
Legendre-like theorems in a general absolute geometry.
, 2007 In this paper the axiomatic basis will be a general absolute plane A = (P,L, α,≡) in the sense of [6], where P and L denote respectively the set of points and the set of lines, α the order structure and ≡ the congruence, and where furthermore the word
Pianta, Silvia +2 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Absolute Value Equation Solution via Dual Complementarity
, 2011 By utilizing a dual complementarity condition, we propose an iterative method for solving the NPhard absolute value equation (AVE): Ax?|x| = b, where A is an n n square matrix.
Mangasarian, Olvi
core