Results 91 to 100 of about 2,104,112 (314)

AN ABSOLUTE DISTINCTION BETWEEN FAITH AND SCIENCE: CONTRAST WITHOUT COMPARTMENTALIZATION

open access: yesZygon, 2018
This article argues for acknowledging the existence of an absolute distinction between faith and science. It is often assumed in the science and religion debate that such a distinction would be ahistorical and uncontextual.
doaj   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Sequence effects in categorization of simple perceptual stimuli [PDF]

open access: yes, 2002
Categorization research typically assumes that the cognitive system has access to a (more or less noisy) representation of the absolute magnitudes of the properties of stimuli and that this information is used in reaching a categorization decision ...
Stewart, Neil   +5 more
core   +1 more source

On Absolute Continuity

open access: yesJournal of Mathematical Analysis and Applications, 1998
The family \({\mathcal F}\) of all figures in \(\mathbb R^m\), finite unions of non-degenerate compact intervals, is topologized with a Hausdorff topology \( \tau\) [ see \textit{L. C. Evans} and \textit{R. F. Gariepy}: ``Measure theory and fine properties of functions'' (1992; Zbl 0804.28001)] and an additive \( \tau\)-continuous real-valued function ...
Buczolich, Zoltán, Pfeffer, Washek F
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Beyond net zero climate targets: a research agenda for absolute environmental sustainability assessment to support decisions at different scales

open access: yesEnvironmental Research Letters
Recent years have seen a wave of net zero targets for greenhouse gas emissions. These represent translations of the Paris Agreement goal of limiting global warming to well below 2 °C to targets for central actors, such as countries, cities and companies.
Anders Bjørn   +7 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

The Class of Absolute Decomposable Inequality Measures [PDF]

open access: yes
We provide a parsimonious axiomatisation of the complete class of absolute nequalityindices. Our approach uses only a weak form of decomposability and does not require a priori that the measures be differentiable.inequality measures, decomposability ...
Frank A Cowell, Kristof Bosmans
core  

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

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