Insulin resistance in school-aged girls with overweight and obesity is strongly associated with elevated white blood cell count and absolute neutrophil count [PDF]
Frontiers in Endocrinology, 2022 BackgroundThe primary objective of the study was to discuss the sex differences in insulin resistance-induced changes in metabolic and inflammatory markers in school-aged children with overweight and obesity.MethodsA cross-sectional study of 800 children
Hong-Mei He +9 more
doaj +5 more sources
Associations between absolute neutrophil count and lymphocyte-predominant breast cancer [PDF]
Breast, 2020 Introduction: Tumor-infiltrating lymphocytes (TILs) might be associated with host-cell mediated immunity, which could be partly reflected by peripheral blood cell counts.
Chang Ik Yoon +8 more
doaj +3 more sources
Association Between Absolute Neutrophil Count and Variation at TCIRG1: The NHLBI Exome Sequencing Project. [PDF]
Genet Epidemiol, 2016 Rosenthal EA +16 more
europepmc +4 more sources
Absolute neutrophil count by Duffy status among healthy Black and African American adults. [PDF]
Blood Adv, 2023 Key Points • The median ANC among Duffy-null individuals is significantly lower than that among Duffy non-null individuals.• Nearly a quarter (23.8%) of Duffy-null individuals had an ANC lower than the reference range (
Merz LE +10 more
europepmc +2 more sources
Clozapine Metabolism is Associated With Absolute Neutrophil Count in Individuals With Treatment-Resistant Schizophrenia. [PDF]
Front Pharmacol, 2021 Up to one-third of those with schizophrenia fail to respond to standard antipsychotics and are considered to have treatment-resistant schizophrenia, a condition for which clozapine is the only evidence-based medication.
Willcocks IR +10 more
europepmc +2 more sources
Development of Duffy Null-Specific Absolute Neutrophil Count Reference Ranges.
JAMA, 2023 This study establishes a Duffy null phenotype–specific absolute neutrophil count reference range to optimize care and improve health equity.
Merz LE +6 more
europepmc +2 more sources
Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count [PDF]
Schizophrenia, 2023 Clozapine is effective at reducing symptoms of treatment-resistant schizophrenia, but it can also induce several adverse outcomes including neutropenia and agranulocytosis. We used linear mixed-effect models and structural equation modelling to determine
Siobhan K. Lock +9 more
doaj +2 more sources
Absolute Neutrophil Count and Mean Platelet Volume in the Blood as Biomarkers to Detect Lung Cancer. [PDF]
Dis Markers, 2020 Objective Inflammation plays an extremely considerable role in the development and progression of malignancies. Absolute neutrophil count (ANC) and mean platelet volume (MPV) in blood are associated with various inflammatory conditions and resulted in ...
Zhu X, Chen Y, Cui Y.
europepmc +2 more sources
Population Pharmacodynamic Model of Neutrophil Margination and Tolerance to Describe Effect of Sarilumab on Absolute Neutrophil Count in Patients with Rheumatoid Arthritis. [PDF]
CPT Pharmacometrics Syst Pharmacol, 2020 Evidence suggests that effects of interleukin‐6 pathway inhibitors sarilumab, tocilizumab, and sirukumab on absolute neutrophil count (ANC) are due to margination of circulating neutrophils into rapidly mobilizable noncirculating pools.
Kovalenko P +8 more
europepmc +2 more sources
Absolute lymphocyte and neutrophil counts in neonatal ischemic brain injury [PDF]
SAGE Open Medicine, 2018 Objectives: This study aimed to identify differences in absolute neutrophils, lymphocytes, and neutrophil-to-lymphocyte ratio between neonates with two forms of ischemic brain injury, hypoxic-ischemic encephalopathy, and acute ischemic stroke, compared ...
Jessica M Povroznik +3 more
doaj +2 more sources