Results 141 to 150 of about 175,779 (327)

Correlation of blood coagulation parameters with comorbidities in COVID-19 patients: A retrospective study

Journal of Medical and Scientific Research
COVID-19 is a respiratory pathogenic strain with the potential to cause severe systemic inflammation and coagulopathy. Moreover, dysfunctional coagulation cascades in diabetes mellitus and an imbalance of cytokines in hypertension and cardiovascular ...
Shuba N, Michael A
doaj   +1 more source

Survival prediction in mesothelioma using a scalable lasso regression model: instructions for use and initial performance using clinical predictors [PDF]

, 2018
Introduction: Accurate prognostication is difficult in malignant pleural mesothelioma (MPM). We developed a set of robust computational models to quantify the prognostic value of routinely available clinical data, which form the basis of published MPM ...
Blyth, Kevin G., Bylesjo, Max, Halligan, Daniel L., Kidd, Andrew C., McGettrick, Michael, Tsim, Selina   +5 more
core   +1 more source

Trajectory of absolute neutrophil counts in patients treated with pegfilgrastim on the day of chemotherapy versus the day after chemotherapy

Cancer Chemotherapy and Pharmacology, 2016
PurposeRisk of infection increases with severity and duration of chemotherapy-induced neutropenia (CIN). Pegfilgrastim is approved for use on the day after chemotherapy to reduce incidence of infection, as manifested by febrile neutropenia (FN), in ...
Yanli Li, Zandra K. Klippel, Xiaolong Shih, Hong Wang, M. Reiner, J. Page   +5 more
semanticscholar   +1 more source

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

Autologous stem cell rescue recipient with neutrophil tissue delivery detected prior to blood engraftment: A case report

eJHaem, 2020
Neutrophil recovery after autologous hematopoietic cell transplantation (ASCT) is affirmed with achievement of an absolute neutrophil count (ANC) of ≥500/µL.
Bushra Tbakhi, Fateeha Furqan, Glynis Scott, Jane L. Liesveld, Omar S. Aljitawi   +4 more
doaj   +1 more source

Irisin‐Loaded Cerium‐Containing Mesoporous Bioactive Glass for Effective Immunomodulation and Odontogenesis of Dental Pulp Cells

Advanced Science, EarlyView.
The Irisin/Ce‐MBGNs delivery system can slowly release myokine Irisin for vital pulp therapy. Irisin/Ce‐MBGNs can enhance mitochondrial function and promote the differentiation of inflammatory macrophages toward M2‐Mφ, thereby regulating the immune response mechanism of inflamed dental pulp.
Mingxin Wang, Yuxin Yang, Jingyao Guo, Yan Chen, Xiaolin Lu, Guangdong Zhang, Yuli Wang, Minhui Yao, Yue Liu, Qian Ma   +9 more
wiley   +1 more source

Cell-Free DNA and CXCL10 Derived from Bronchoalveolar Lavage Predict Lung Transplant Survival. [PDF]

, 2019
Standard methods for detecting chronic lung allograft dysfunction (CLAD) and rejection have poor sensitivity and specificity and have conventionally required bronchoscopies and biopsies.
Damm, Izabella, Liberto, Juliane M, Sarwal, Minnie M, Sarwal, Reuben D, Sigdel, Tara K, Vanaudenaerde, Bart M, Verleden, Geert M, Verleden, Stijn E, Vos, Robin, Watson, Drew, Yang, Joshua YC, Zarinsefat, Arya   +11 more
core   +2 more sources

Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma

Advanced Science, EarlyView.
This study develops a nested resampling machine learning framework to establish the Immune Glioma Survival Signature (IGLoS), which stratifies glioma patients and predicts immunotherapy resistance. Multi‐omics analyses reveal TRAF3IP3 as a pivotal regulator of PD‐L1 expression and T‐cell exhaustion via ERK‐NFATC2 signaling.
Yanbo Yang, Fei Wang, Yulian Zhang, Run Huang, Chuanpeng Zhang, Lu Zhao, Hanhan Dang, Xinyu Tao, Yue Lu, Dengfeng Lu, Yunsheng Zhang, Kun He, Jiancong Weng, Zhouqing Chen, Zhong Wang, Yanbing Yu   +15 more
wiley   +1 more source

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Hepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li   +18 more
wiley   +1 more source

Blood neutrophil counts in HIV-infected patients with cryptococcal meningitis: Association with mortality.

PLoS ONE, 2018
BackgroundThe mortality from cryptococcal meningitis remains high, despite the availability of antiretroviral therapy (ART) and amphotericin-based fungal regimens. The role of neutrophils in cryptococcosis is controversial.
Abdu Kisekka Musubire, David B Meya, Joshua Rhein, Graeme Meintjes, Paul R Bohjanen, Edwin Nuwagira, Conrad Muzoora, David R Boulware, Kathy Huppler Hullsiek, COAT and ASTRO trial teams   +9 more
doaj   +1 more source