Results 41 to 50 of about 11,192,626 (307)

Absolute entropy and the observer’s no-boundary state

Journal of High Energy Physics
We investigate the no-boundary proposal for closed universes with an observer. We argue that the observer’s no-boundary state is the identity operator on the physical Hilbert space, i.e., the maximum entropy state and show this explicitly in Jackiw ...
Andreas Blommaert, Jonah Kudler-Flam, Erez Y. Urbach   +2 more
doaj   +1 more source

The Competency of Administrative Court in Adjudicating State Financial Losses Report Dispute in Indonesia

Sriwijaya Law Review, 2020
The debate on the absolute competency of the State Administrative Court in Indonesia to set the dispute over the State Financial Losses Report (LHPKKN) is proved to have caused dissenting opinion.
Helmi Helmi, Fauzi Syam, Harry Setya Nugraha, Retno Kusniati   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Autocracy and the Modern State: Case Study of Reza Shah’s Government [PDF]

دولت‌پژوهی, 2016
Purpose: There are various approaches to study the modern state in Iran including the Marxist approach, Patrimonial approach and the Oriental despotism approach.
Hamidreza Rahmanizadeh Dehkordi, Mohamad Medi Zanjani   +1 more
doaj   +1 more source

Classification of Blood Volume Decompensation State via Machine Learning Analysis of Multi-Modal Wearable-Compatible Physiological Signals

Sensors, 2022
This paper presents a novel computational algorithm to estimate blood volume decompensation state based on machine learning (ML) analysis of multi-modal wearable-compatible physiological signals.
Yekanth Ram Chalumuri, Jacob P. Kimball, Azin Mousavi, Jonathan S. Zia, Christopher Rolfes, Jesse D. Parreira, Omer T. Inan, Jin-Oh Hahn   +7 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Debiased orbit and absolute-magnitude distributions for near-Earth objects [PDF]

Icarus (New York, N.Y. 1962), 2018
The debiased absolute-magnitude and orbit distributions as well as source regions for near-Earth objects (NEOs) provide a fundamental frame of reference for studies of individual NEOs and more complex population-level questions.
M. Granvik, A. Morbidelli, R. Jedicke, B. Bolin, W. Bottke, E. Beshore, D. Vokrouhlický, D. Nesvorný, P. Michel   +8 more
semanticscholar   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Scope 2 and market-based accounting - workshop report

Carbon Management
This report summarises the presentations and discussions at an international workshop on ‘Scope 2 and Market-based Accounting’, held on 28th April 2023 at the Technical University of Denmark (DTU).
Matthew Brander, Jesse Backstrom, Michael Gillenwater, Lissy Langer, Olivier Corradi, Malte Schäfer, Jon  Sigvert, Ciril Wakounig, Anders Bjørn   +8 more
doaj   +1 more source