Results 61 to 70 of about 779,948 (264)

Conception of Absolute and Relative Space in Philosophy and Their Relationship to the Territoriality of the Modern State

open access: yesCzech Journal of International Relations, 2010
The paper seeks to find the relationship between the philosophical debate on absolute and relative space and the IR debate on territoriality. It shows the relation between the absolute space concept and the territorial definition of the modern state. It
Tomáš Weiss
doaj  

History of the Equation of State of Seawater [PDF]

open access: yesOceanography, 2010
As one of few who have been involved in the equation of state of seawater over the last 40 years, the author was invited to review some of the history behind its early development and also the more recent thermodynamic equation of state.
Frank J. Millero
doaj  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Vibrational Circular Dichroism: A New Tool for the Solution-State Determination of the Structure and Absolute Configuration of Chiral Natural Product Molecules

open access: yesNatural Product Communications, 2008
Vibrational circular dichroism (VCD) has been used in recent years to determine the absolute configuration of a number of natural product chiral molecules.
Laurence A. Nafie
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Polytopes of Absolutely Wigner Bounded Spin States

open access: yesQuantum
Quasiprobability has become an increasingly popular notion for characterising non-classicality in quantum information, thermodynamics, and metrology. Two important distributions with non-positive quasiprobability are the Wigner function and the Glauber-Sudarshan function.
Denis, Jérôme   +3 more
openaire   +3 more sources

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Adaptability of simulation state equation of hydrogen-blended natural gas pipeline

open access: yesJournal of Pipeline Science and Engineering
At present, hydrogen transportation in natural gas pipeline network is the main mode of hydrogen energy transportation. Accurate description of the physical parameters of mixed gas is the key to the simulation of hydrogen-blended natural gas pipeline ...
Bolin Qiu   +4 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

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