Results 51 to 60 of about 94,612 (306)
British Journal of Clinical Pharmacology, EarlyView.Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza +12 more
wiley +1 more source
Digital DiagnosticsThe article presents an assessment of body composition markers measured by imaging in clinical practice for postmenopausal and aging women. Body composition changes with aging and is specifically affected by endocrinological changes occurring with ...
Maria P. Aparisi Gómez +8 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Regulatory limits on metformin co‐administered with dolutegravir (DTG) derive from healthy‐volunteer studies in which DTG increased metformin exposure by 79% through organic cation transporter 2 inhibition, prompting a 1,000 mg/day metformin dose restriction.
Rohan M. Benecke +3 more
wiley +1 more source
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Bone loss is a severe and often irreversible complication of anorexia nervosa (AN), yet the genetic mechanisms underlying this comorbidity remain underexplored. This study focuses on constructing a comprehensive genetic architecture between AN and estimated calcaneal bone mineral density (eBMD).
Tao Han +14 more
wiley +1 more source
Proceedings, 2019 Background: Dual energy X-ray absorptiometry (DXA) is a well-regarded device for primarilymeasuring bone mineral density (BMD) and body composition. [...]
Maryam Delshad +5 more
doaj +1 more source
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective To identify data‐driven body composition phenotypes in patients with moderate‐to‐extreme anorexia nervosa (AN) using machine learning (ML) clustering of bioelectrical impedance analysis (BIA) parameters, and to test whether these phenotypes have specific psychopathological and childhood trauma profiles while correlating with early ...
Emanuele Cassioli +12 more
wiley +1 more source
, 2019 Intraclass correlation coefficients against dual emission X-ray absorptiometry (N = 437; ICC with 95% confidence Intervals).
You Fu (6490688) +2 more
core +1 more source
Severe skeletal fragility in SCN8A‐related developmental and epileptic encephalopathy
Epilepsia, EarlyView.Abstract In this child with a phenotype compatible with the SCN8A gain‐of‐function spectrum, more than 20 bone fractures were documented. Together with previously reported cases, these observations raise the possibility that skeletal fragility may represent an underrecognized feature of the clinical spectrum associated with pathogenic SCN8A variants ...
Adélia Maria de Miranda Henriques‐Souza +1 more
wiley +1 more source
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Pregnancy‐ and lactation‐associated osteoporosis (PLO) is a syndrome characterized by fragility fractures (most commonly vertebral, often multiple) occurring in late pregnancy or the early postpartum period. This position statement summarizes the current knowledge of PLO, and the recommended procedure for assessment, diagnosis and treatment ...
Peyman Hadji +20 more
wiley +1 more source
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Risk‐reducing salpingo‐oophorectomy (RRSO) is the cornerstone of ovarian cancer prevention for women with hereditary cancer predisposition syndromes. When performed before natural menopause, however, RRSO induces immediate surgical menopause, with vasomotor symptoms, sexual dysfunction, accelerated bone loss, and potential long‐term ...
Agnaldo Lopes da Silva Filho +7 more
wiley +1 more source