Results 11 to 20 of about 1,111,695 (149)

Autologous adipose-derived regenerative cell therapy modulates development of hypertrophic scarring in a red Duroc porcine model

Stem Cell Research & Therapy, 2017
Background Effective prevention and treatment of hypertrophic scars (HTSs), a common consequence of deep-partial thickness injury, remain a significant clinical challenge.
Philippe Foubert, Diana Zafra, Mike Liu, Rohit Rajoria, Damian Gutierrez, Mayer Tenenhaus, John K. Fraser   +6 more
doaj   +1 more source

3D Printing of Mini Tablets for Pediatric Use

Pharmaceuticals, 2021
In the treatment of pediatric diseases, suitable dosages and dosage forms are often not available for an adequate therapy. The use of innovative additive manufacturing techniques offers the possibility of producing pediatric dosage forms.
Julius Krause, Laura Müller, Dorota Sarwinska, Anne Seidlitz, Malgorzata Sznitowska, Werner Weitschies   +5 more
doaj   +1 more source

Course of disease and risk factors for hospitalization in outpatients with a SARS-CoV-2 infection

Scientific Reports, 2022
We analyzed symptoms and comorbidities as predictors of hospitalization in 710 outpatients in North-East Germany with PCR-confirmed SARS-CoV-2 infection.
Eik Schäfer, Christian Scheer, Karen Saljé, Anja Fritz, Thomas Kohlmann, Nils-Olaf Hübner, Matthias Napp, Lizon Fiedler-Lacombe, Dana Stahl, Bernhard Rauch, Matthias Nauck, Uwe Völker, Stephan Felix, Guglielmo Lucchese, Agnes Flöel, Stefan Engeli, Wolfgang Hoffmann, Klaus Hahnenkamp, Mladen V. Tzvetkov   +18 more
doaj   +1 more source

An In Vitro Model to Investigate the Potential of Solid Dispersions to Form Pharmacobezoars

Pharmaceutics, 2022
The formation of pharmacobezoars from suspensions of spray-dried amorphous solid dispersions (SD-ASDs) of new chemical entities (NCEs) and hydroxypropyl methylcellulose acetate succinate (HPMC-AS) represents a non-compound related adverse effect in ...
Hannes Gierke, Kerstin Schaefer, Lukas Gerlich, Ann-Cathrin Willmann, Verena Bialetzki, Georg Boeck, Teresa Pfrommer, Thomas Nolte, Werner Weitschies   +8 more
doaj   +1 more source

Influence of Siluron® insertion on model drug distribution in the simulated vitreous body

Current Directions in Biomedical Engineering, 2016
Biorelevant in vitro test systems may be helpful to understand the in vivo behaviour of modern intravitreal dosage forms such as implants and injections.
Stein Sandra, Bogdahn Malte, Weitschies Werner, Seidlitz Anne   +3 more
doaj   +1 more source

Mitochondrial reactive oxygen species modify extracellular vesicles secretion rate

FASEB BioAdvances, 2023
Extracellular vesicle (EV) secretion rate is stimulated by hypoxia that causes increased reactive oxygen species (ROS) production by the mitochondrial electron transport chain (ETC) and hypoxia‐induced factor (HIF)‐1 signaling; however, their ...
Mikkel Ø. Nørgård, Philip M. Lund, Nazmie Kalisi, Thomas L. Andresen, Jannik B. Larsen, Stefan Vogel, Per Svenningsen   +6 more
doaj   +1 more source

Evaluation of Pharmacobezoar Formation from Suspensions of Spray-Dried Amorphous Solid Dispersions: An MRI Study in Rats

Pharmaceutics, 2023
Spray-dried amorphous solid dispersions of new chemical entities and pH-dependent soluble polymer hydroxypropyl methylcellulose acetate succinate (HPMC-AS) were found to form solid agglomerates in the gastrointestinal tract of rodents after oral ...
Hannes Gierke, Susan Mouchantat, Sabine Berg, Michael Grimm, Stefan Hadlich, Marie-Luise Kromrey, Thomas Nolte, Teresa Pfrommer, Vincent Rönnpagel, Adrian Rump, Kerstin Schaefer, Ann-Cathrin Willmann, Werner Weitschies   +12 more
doaj   +1 more source

Ex Vivo Visualization of Distribution of Intravitreal Injections in the Porcine Vitreous and Hydrogels Simulating the Vitreous

Pharmaceutics, 2023
The characterization of intravitreal dosage forms with regard to their behavior in vivo is usually explored in preclinical development through animal studies. In vitro vitreous substitutes (VS) to simulate the vitreous body for preclinical investigations
Tobias Auel, Lara Paula Scherke, Stefan Hadlich, Susan Mouchantat, Michael Grimm, Werner Weitschies, Anne Seidlitz   +6 more
doaj   +1 more source

Various effects of repeated rifampin dosing on coproporphyrin levels in humans

Clinical and Translational Science, 2023
In recent years, the identification of endogenous substrates as biomarkers became an uprising topic. Particularly coproporphyrins (CPs), byproducts of heme biosynthesis, are intensely investigated as biomarkers for predicting interactions with the ...
Jonny Kinzi, Markus Grube, Karin Brecht, Isabell Seibert, Werner Siegmund, Henriette E. Meyer zu Schwabedissen   +5 more
doaj   +1 more source

Isobutyrylcarnitine as a Biomarker of OCT1 Activity and Interspecies Differences in its Membrane Transport

Frontiers in Pharmacology, 2021
Genome-wide association studies have identified an association between isobutyrylcarnitine (IBC) and organic cation transporter 1 (OCT1) genotypes. Higher IBC blood concentrations in humans with active OCT1 genotypes and experimental studies with mouse ...
Ole Jensen, Johannes Matthaei, Henry G. Klemp, Marleen J. Meyer, Jürgen Brockmöller, Mladen V. Tzvetkov   +5 more
doaj   +1 more source