Results 31 to 40 of about 1,836,494 (319)

Organic Cation Transporter 1 an Intestinal Uptake Transporter: Fact or Fiction?

open access: yesFrontiers in Pharmacology, 2021
Intestinal transporter proteins are known to affect the pharmacokinetics and in turn the efficacy and safety of many orally administered drugs in a clinically relevant manner.
Christoph Wenzel   +2 more
doaj   +1 more source

A comparison of theacrine and methylliberine with caffeine as salivary markers for determining gastric emptying

open access: yesInternational Journal of Pharmaceutics: X
Gastric emptying is a critical determinant of the pharmacokinetics of orally administered drugs. A key limitation in studies using caffeine as a marker for gastric emptying is the requirement for prior caffeine abstinence, which can complicate study ...
Toni Wildgrube   +6 more
doaj   +1 more source

Effects of HSD11B1 knockout and overexpression on local cortisol production and differentiation of mesenchymal stem cells

open access: yesFrontiers in Bioengineering and Biotechnology, 2022
Exogenous glucocorticoids increase the risk for osteoporosis, but the role of endogenous glucocorticoids remains elusive. Here, we describe the generation and validation of a loss- and a gain-of-function model of the cortisol producing enzyme 11β-HSD1 ...
Angelique Kragl   +10 more
doaj   +1 more source

Evaluation of Multiangle Absorption Photometry for Measuring Aerosol Light Absorption

open access: yes, 2005
A new multiangle absorption photometer for the measurement of aerosol light absorption was recently introduced that builds on the simultaneous measurement of radiation transmitted through and scattered back from a particle-loaded fiber filter at multiple
Arnott, W.P.   +5 more
core   +1 more source

Using integrating spheres as absorption cells: path-length distribution and application of Beer's law [PDF]

open access: yes, 2009
We have modeled the path-length distribution in an integrating sphere used as a multipass optical cell for absorption measurements. The measured radiant flux as a function of analyte concentration is nonlinear as a result, deviating from that expected
Hodgkinson, Jane   +2 more
core   +1 more source

Glycerol gelatin for 3D-printing of implants using a paste extrusion technique

open access: yesCurrent Directions in Biomedical Engineering, 2017
Fused deposition modeling as an additive manufacturing technique has gained great popularity for the fabrication of medical devices as well as pharmaceutical dosage forms over the last years.
Kempin Wiebke   +3 more
doaj   +1 more source

Individualized, Additively Manufactured Drug-Releasing External Ear Canal Implant for Prevention of Postoperative Restenosis: Development, In Vitro Testing, and Proof of Concept in an Individual Curative Trial

open access: yesPharmaceutics, 2022
Postoperative restenosis in patients with external ear canal (EEC) atresia or stenosis is a common complication following canaloplasty. Our aim in this study was to explore the feasibility of using a three dimensionally (3D)-printed, patient ...
Farnaz Matin-Mann   +11 more
doaj   +1 more source

Impact of Tablet Size and Shape on the Swallowability in Older Adults

open access: yesPharmaceutics, 2023
Older adults represent the major target population for oral medications, due to the high prevalence of multimorbidity. To allow for successful pharmacological treatments, patients need to adhere to their medication and, thus, patient-centric drug ...
Henriette Hummler   +8 more
doaj   +1 more source

On the relationship between auroral absorption, electrojets currents and plasma convection [PDF]

open access: yes, 2009
In this study, the relationship between auroral absorption, electrojet currents, and ionospheric plasma convection velocity is investigated using a series of new methods where temporal correlations are calculated and analysed for different events and ...
R. A. Makarevich   +10 more
core   +1 more source

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