Results 41 to 50 of about 1,152,810 (269)
In vitro simulation of distribution processes following intramuscular injection
Current Directions in Biomedical Engineering, 2016 There is an urgent need for in vitro dissolution test setups for intramuscularly applied dosage forms. Especially biorelevant methods are needed to predict the in vivo behavior of newly developed dosage forms in a realistic way.
Probst Mareike +3 more
doaj +1 more source
Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas
Pediatric Blood &Cancer, EarlyView.ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall +2 more
wiley +1 more source
In Vitro Methods for Evaluating Drug Release of Vaginal Ring Formulations—A Critical Review
Pharmaceutics, 2019 The vagina is a promising site for both local and systemic drug delivery and represents an interesting administration route for compounds with poor oral bioavailability.
Katharina Tietz, Sandra Klein
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Leukemia is the most common childhood cancer in Mexico, and acute lymphoblastic leukemia (ALL) is the most frequent subtype. Exposure to high concentrations of benzene has been associated with ALL incidence, particularly in urban areas. This study evaluated the relationship between distance to benzene emission sources and the number
Orlando Rivera Zurita +5 more
wiley +1 more source
Ex vivo perfusion model of mouse liver and its application to analyze the effects of OCT1 deficiency
Frontiers in PharmacologyIntroductionThe liver plays a critical role in drug pharmacokinetics. In in vivo experiments, it is difficult to isolate the liver’s contribution to drug systemic concentrations from that of the intestine and kidneys.
Vincent Rönnpagel +5 more
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THE ABSORPTION OF ADRENALIN [PDF]
Journal of Experimental Medicine, 1923 1. Adrenalin solution given subcutaneously is usually rapidly absorbed, probably by lymphatic channels. 2. The speed of this process may be influenced by the circulation rate. 3. The relative amounts of adrenalin at any moment unabsorbed at the site of inoculation, carried in the circulating fluids, and taken up by the ...
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Neuroblastoma's complex, heterogeneous biology poses significant diagnostic and therapeutic challenges, often requiring caregivers to absorb complex information and participate in time‐sensitive decisions. However, caregivers often feel unprepared to evaluate options.
Vickie Buenger +8 more
wiley +1 more source
Assessment of new scientific studies on human in vitro dermal absorption
EFSA Journal, 2015 This EFSA scientific report describes the results from the evaluation of new human in vitro studies on dermal absorption made available by European Crop Protection Association (ECPA) and the German public organisation Bundesinstitut für Risikobewertung ...
EFSA Working Group on Dermal Absorption
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source