Results 41 to 50 of about 1,016,885 (202)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Measurement of Wavelength-Resolved Light Absorption by Aerosols Utilizing a UV-VIS Extinction Cell [PDF]
, 2005 The principle, technical details, and performance of the long path extinction spectrometer (LOPES), a new folded-path extinction cell with a spectral range from the mid-UV (200 nm) to the near infrared (1015 nm), is presented.
Schurath, Ulrich +23 more
core +1 more source
FEBS Open BioThe multidrug resistance protein 4 (MRP4/ABCC4) is a versatile efflux pump, known to transport several drugs but also signaling molecules such as cyclic nucleotides and lipid mediators.
Debora Singer +7 more
doaj +1 more source
In vitro simulation of distribution processes following intramuscular injection
Current Directions in Biomedical Engineering, 2016 There is an urgent need for in vitro dissolution test setups for intramuscularly applied dosage forms. Especially biorelevant methods are needed to predict the in vivo behavior of newly developed dosage forms in a realistic way.
Probst Mareike +3 more
doaj +1 more source
Pharmaceutics, 2021 The central nervous system (CNS) is an important pharmacological target, but it is very effectively protected by the blood–brain barrier (BBB), thereby impairing the efficacy of many potential active compounds as they are unable to cross this barrier ...
Anima M. Schäfer +2 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Inter-subject variability in oral drug absorption [PDF]
, 2015 A low and highly variable bioavailability is often the main reason for the failure of the development of a drug intended for oral delivery. Focusing on absorption instead of bioavailability from oral administration enables the identification and ...
Rabbie, S
core
Using integrating spheres as absorption cells: path-length distribution and application of Beer's law [PDF]
, 2009 We have modeled the path-length distribution in an integrating sphere used as a multipass optical cell for absorption measurements. The measured radiant flux as a function of analyte concentration is nonlinear as a result, deviating from that expected
Hodgkinson, Jane +2 more
core +1 more source
Ex vivo perfusion model of mouse liver and its application to analyze the effects of OCT1 deficiency
Frontiers in PharmacologyIntroductionThe liver plays a critical role in drug pharmacokinetics. In in vivo experiments, it is difficult to isolate the liver’s contribution to drug systemic concentrations from that of the intestine and kidneys.
Vincent Rönnpagel +5 more
doaj +1 more source
In Vitro Methods for Evaluating Drug Release of Vaginal Ring Formulations—A Critical Review
Pharmaceutics, 2019 The vagina is a promising site for both local and systemic drug delivery and represents an interesting administration route for compounds with poor oral bioavailability.
Katharina Tietz, Sandra Klein
doaj +1 more source