Results 51 to 60 of about 1,152,810 (269)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Study on CO2 Absorbent of DETA and TEA Mixed Amine Solution

发电技术, 2022
In order to solve the problems of high regeneration energy consumption and poor recycling rate in the CO2 capture process of traditional absorbents, the research and development of new high-efficiency and low-energy-consumption solvents has become the ...
ZHANG Huan, WANG Li, YE Yi, ZHAO Xinglei
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Nonlinear Absorptions

Journal of Functional Analysis, 1993
Let \(A\) be an \(m\)-completely accretive operator in \(L^ 1(\Omega)\), where \((\Omega,{\mathcal B},\mu)\) is a \(\sigma\)-finite measure space. Let \(j: \Omega\times\mathbb{R}\to [0,\infty]\) be measurable in \(x\in\Omega\), convex and lower semicontinuous in \(r\in\mathbb{R}\), with \(j(x,0)=0\).
Benilan, P., Wittbold, P.
openaire   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Individual use of self-medication and other remedies in COVID-19 outpatients in Western-Pomerania

Scientific Reports
We analyzed data from positively tested COVID-19 outpatients to describe self-medication with OTC drugs and use of other remedies against symptoms of SARS-CoV-2 infection.
Svea Stüdemann, Eik Schäfer, Klaus Hahnenkamp, Mladen V. Tzvetkov, Stefan Engeli   +4 more
doaj   +1 more source

Exopeptidase combination enhances the degradation of isotopically labelled gluten immunogenic peptides in humans

Frontiers in Immunology
IntroductionCeliac disease is a common autoimmune-like enteropathy caused by an aberrant response to incompletely digested dietary gluten. Gluten immunogenic peptides including the immunodominant 33-mer are thought to be resistant to proteolytic ...
Sulayman Mourabit, Sarah Römer, Erin R. Bonner, Fabian Winter, Julian Tschollar, Mladen V. Tzvetkov, Werner Weitschies, Stefan Engeli, Werner Tschollar   +8 more
doaj   +1 more source

MR imaging of model drug distribution in simulated vitreous

Current Directions in Biomedical Engineering, 2015
The in vitro and in vivo characterization of intravitreal injections plays an important role in developing innovative therapy approaches. Using the established vitreous model (VM) and eye movement system (EyeMoS) the distribution of contrast agents with ...
Stein Sandra, Simroth-Loch Christian, Langner Sönke, Hadlich Stefan, Stachs Oliver, Grabow Niels, Guthoff Rudolf, Weitschies Werner, Seidlitz Anne   +8 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source