Results 31 to 40 of about 1,111,695 (149)

Ex vivo perfusion model of mouse liver and its application to analyze the effects of OCT1 deficiency

Frontiers in Pharmacology
IntroductionThe liver plays a critical role in drug pharmacokinetics. In in vivo experiments, it is difficult to isolate the liver’s contribution to drug systemic concentrations from that of the intestine and kidneys.
Vincent Rönnpagel, Felix Morof, Giuliano Ciarimboli, Markus Grube, Marleen J. Meyer-Tönnies, Mladen V. Tzvetkov   +5 more
doaj   +1 more source

Assessment of new scientific studies on human in vitro dermal absorption

EFSA Journal, 2015
This EFSA scientific report describes the results from the evaluation of new human in vitro studies on dermal absorption made available by European Crop Protection Association (ECPA) and the German public organisation Bundesinstitut für Risikobewertung ...
EFSA Working Group on Dermal Absorption
doaj   +1 more source

Nonlinear Absorptions

Journal of Functional Analysis, 1993
Let \(A\) be an \(m\)-completely accretive operator in \(L^ 1(\Omega)\), where \((\Omega,{\mathcal B},\mu)\) is a \(\sigma\)-finite measure space. Let \(j: \Omega\times\mathbb{R}\to [0,\infty]\) be measurable in \(x\in\Omega\), convex and lower semicontinuous in \(r\in\mathbb{R}\), with \(j(x,0)=0\).
Benilan, P., Wittbold, P.
openaire   +2 more sources

Study on CO2 Absorbent of DETA and TEA Mixed Amine Solution

发电技术, 2022
In order to solve the problems of high regeneration energy consumption and poor recycling rate in the CO2 capture process of traditional absorbents, the research and development of new high-efficiency and low-energy-consumption solvents has become the ...
ZHANG Huan, WANG Li, YE Yi, ZHAO Xinglei
doaj   +1 more source

Individual use of self-medication and other remedies in COVID-19 outpatients in Western-Pomerania

Scientific Reports
We analyzed data from positively tested COVID-19 outpatients to describe self-medication with OTC drugs and use of other remedies against symptoms of SARS-CoV-2 infection.
Svea Stüdemann, Eik Schäfer, Klaus Hahnenkamp, Mladen V. Tzvetkov, Stefan Engeli   +4 more
doaj   +1 more source

Exopeptidase combination enhances the degradation of isotopically labelled gluten immunogenic peptides in humans

Frontiers in Immunology
IntroductionCeliac disease is a common autoimmune-like enteropathy caused by an aberrant response to incompletely digested dietary gluten. Gluten immunogenic peptides including the immunodominant 33-mer are thought to be resistant to proteolytic ...
Sulayman Mourabit, Sarah Römer, Erin R. Bonner, Fabian Winter, Julian Tschollar, Mladen V. Tzvetkov, Werner Weitschies, Stefan Engeli, Werner Tschollar   +8 more
doaj   +1 more source

MR imaging of model drug distribution in simulated vitreous

Current Directions in Biomedical Engineering, 2015
The in vitro and in vivo characterization of intravitreal injections plays an important role in developing innovative therapy approaches. Using the established vitreous model (VM) and eye movement system (EyeMoS) the distribution of contrast agents with ...
Stein Sandra, Simroth-Loch Christian, Langner Sönke, Hadlich Stefan, Stachs Oliver, Grabow Niels, Guthoff Rudolf, Weitschies Werner, Seidlitz Anne   +8 more
doaj   +1 more source

The effect of black tea and water temperature on the disintegration of gelatine and HPMC capsules, tested with the paddle device, GastroDuo and in vivo pharmacokinetics: Much ado about little

International Journal of Pharmaceutics: X
Fluid co-administered with oral medication directly affects its behaviour. Often, people use fluids other than water when taking their medications. Capsules (mainly gelatine- and HPMC-based) are widely used solid oral dosage forms.
Dorota Sarwinska, Mathilde Leyh, Constantin Foja, Theodora Tzakri, Philipp Schick, Felix Morof, Julius Krause, James Mann, Richard Barker, Mladen Vassilev Tzvetkov, Werner Weitschies, Michael Grimm   +11 more
doaj   +1 more source

Self‐Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?

Advanced Science, 2019
Given their durability and long‐term stability, self‐healable hydrogels have, in the past few years, emerged as promising replacements for the many brittle hydrogels currently being used in preclinical or clinical trials. To this end, the incompatibility
Sepehr Talebian, Mehdi Mehrali, Nayere Taebnia, Cristian Pablo Pennisi, Firoz Babu Kadumudi, Javad Foroughi, Masoud Hasany, Mehdi Nikkhah, Mohsen Akbari, Gorka Orive, Alireza Dolatshahi‐Pirouz   +10 more
doaj   +1 more source

Increased coproporphyrin serum levels in healthy volunteers treated with the cholesterol uptake inhibitor ezetimibe

Clinical and Translational Science
Ezetimibe undergoes glucuronidation that results in the active metabolite ezetimibe phenoxy‐glucuronide (ezetimibe‐glucuronide). This phase‐II metabolite was shown to interact with the clinically relevant hepatic transporter organic anion transporting ...
Jonny Kinzi, Markus Grube, Isabell Seibert, Werner Siegmund, Henriette E. Meyer zu Schwabedissen   +4 more
doaj   +1 more source