Results 41 to 50 of about 82,443 (252)
Indian Journal of Psychiatric Nursing, 2014 Substance use disorder is considered as a chronic relapsing disorder characterized by compulsive, often uncontrollable, substance seeking and substance use in the face of negative consequences.
A Markose +10 more
doaj +1 more source
Advanced Science, EarlyView.A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil +7 more
wiley +1 more source
Kaohsiung Journal of Medical Sciences, 2008 The aim of this study was to examine the factors related to abstinence from heroin and methamphetamine (MAMP) use and to seeking help from medical services in Taiwanese drug users.
Chia-Nan Yen +5 more
doaj +1 more source
Effects of abstinence from opioids on self-reported craving and sleep
Cogent Psychology, 2020 Abstinence-based treatment of opioid use disorder has always been faced with the probability of an increase in craving, which potentially results in relapse. Moreover, sleep problems are predominant among patients with abstinence treatment.
Hamidreza Fathi +4 more
doaj +1 more source
Advanced Science, EarlyView.This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao +8 more
wiley +1 more source
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
Frontiers in Neuroscience, 2021 Hippocampal neurodegeneration is a consequence of excessive alcohol drinking in alcohol use disorders (AUDs), however, recent studies suggest that females may be more susceptible to alcohol-induced brain damage. Adult hippocampal neurogenesis is now well
Natalie N. Nawarawong +5 more
doaj +1 more source
Advanced Science, EarlyView.Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner +14 more
wiley +1 more source
Application of glycyrrhizinic acid in treatment of patients with alcoholic liver disease
Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2009 Aim of investigation. To estimate of clinical efficacy and safety profile of parenteral form of «Phosphogliv» preparation containing glycyrrhizin and essential phospholipids, at treatment of patients with alcoholic liver disease.Materials and methods ...
I. G. Nikitin +5 more
doaj
White Matter Changes in HIV+ Women with a History of Cocaine Dependence
Frontiers in Neurology, 2017 Cocaine use is associated with the transmission of human immunodeficiency (HIV) virus through risky sexual behavior. In HIV+ individuals, cocaine use is linked with poor health outcomes, including HIV-medication non-adherence and faster disease ...
Kathryn-Mary Wakim +9 more
doaj +1 more source