Results 61 to 70 of about 84,772 (258)

Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug‐Resistant Tuberculosis

Clinical Pharmacology &Therapeutics, EarlyView.
Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell, Antonio Lombardi, William Brumskine, Lali Mikiashvili, Kim Boekelheide, Joanna Moreira, Alda Holsta, Matthew Betteridge, Lindsay Thompson, Angela Crook, Paul Bruinenberg, Maria Beumont, Eugene Sun, Francesca Conradie   +13 more
wiley   +1 more source

Neonatal Abstinence Syndrome

Kathmandu University Medical Journal, 2012
Intrauterine exposure to drugs by mothers is not an uncommon finding ine our society. Due to the mother’s suppression of a medical history, the diagnosis of neonatal abstinence syndrome is often missed. We report a case of a term, female, newborn, who presented with the following features;e restlessness, inconsolable crying, along with sweating ...
K K, Mishra, N, Chopra, A, Dudeja, V, Datta, A, Saili, A K, Dutta   +5 more
openaire   +3 more sources

A Novel Workflow for Fast Elucidation of Drug Metabolites for Screening—Combining In Silico Metabolite Prediction With Trapped Ion Mobility QTOF‐MS

Drug Testing and Analysis, EarlyView.
UHPLC‐timsTOF‐MS with in silico prediction and automated annotation enabled rapid identification of quetiapine metabolites from pHLMs, facilitating their inclusion in targeted LC‐QTOF‐MS urine screening and improving biomarker detection for toxicological applications.
Annette Zschiesche, Birgit Schneider, Ilona Nordhorn, Carsten Baessmann, Laura M. Huppertz, Jürgen Kempf   +5 more
wiley   +1 more source

Neurocognitive Recovery in Abstinent Patients with Alcohol Use Disorder: A Scoping Review for Associated Factors

Neuropsychiatric Disease and Treatment, 2023
Jeroen Staudt,1,2 Tim Kok,1 Hein A de Haan,1,3 Serge JW Walvoort,4 Jos IM Egger2,5,6 1Tactus Addiction Treatment, Deventer, the Netherlands; 2Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands; 3Nijmegen ...
Staudt J, Kok T, de Haan HA, Walvoort SJW, Egger JIM   +4 more
doaj  

Examining Phosphatidylethanol (PEth) Formation Rates Within and Between Subjects in Ex Vivo Whole Blood

Drug Testing and Analysis, EarlyView.
PEth formation rate increased with increasing ethanol concentration with variability between participants but was mostly consistent within‐subject. No relationship was observed between phosphatidylcholine concentrations and PEth formation rates. PEth concentrations should be used to monitor an individual's ethanol use over time, rather than compared ...
Haidyn G. Stark, Jesus J. Sanchez, Nathalie Hill‐Kapturczak, John D. Roache, Brett C. Ginsburg   +4 more
wiley   +1 more source

Segmental Hair Analysis of Diphenhydramine and Cyclizine Following a Single Dose

Drug Testing and Analysis, EarlyView.
A single oral dose of diphenhydramine and cyclizine can be quantified in human head hair for a minimum of 5 months and, in certain cases, for up to 1 year following intake. Among 12 study participants, the measured concentrations ranged from 0 to 610 pg/mg within 1 year post‐intake.
Jan Bílek, Marie Katrine Klose Nielsen, Robert Kronstrand, Sys Stybe Johansen   +3 more
wiley   +1 more source

Feasibility and Preliminary Efficacy of a Guided Self‐Help Digital Intervention for Adults With Food Insecurity, Recurrent Binge Eating, and Type 2 Diabetes Mellitus: A Pilot Trial

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Food insecurity is increasingly linked to binge eating and weight‐related health issues like type 2 diabetes mellitus, but no eating disorder interventions have been tested among individuals with food insecurity. We conducted a single‐arm pilot test of FoodSteps‐FI, a guided self‐help digital intervention for binge eating adapted for
Andrea K. Graham, Rebecca L. Flynn, Isabel R. Rooper, Chidiebere Azubuike, Lindsay D. Lipman, Adrian Ortega, Leah M. Parsons, Graham C. Miller, Damien Lekkas, Jennifer E. Wildes   +9 more
wiley   +1 more source

Sexual risk related behaviour among youth living with HIV in central Uganda: implications for HIV prevention

The Pan African Medical Journal, 2016
Background: As young people living with HIV grow their sexual behaviour and it's implication on HIV prevention is of concern. This study describes the sexual risk related-behaviours and factors associated with abstinence among Youth Living with HIV in ...
Racheal Ankunda, Lynn Muhimbuura Atuyambe, Noah Kiwanuka   +2 more
doaj   +1 more source

Eating Disorder Symptom Severity Decreases in Fasting Muslim Women in the United States During Ramadan: A Preliminary Longitudinal Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Although dietary restraint is associated with loss of control (LOC) eating, less is known about associations between food restraint and religious fasting. During the month of Ramadan, Muslims fast from sunrise to sunset. Ramadan fasting may be associated with negative consequences related to eating and body image; however, increased ...
Hoor Ul Ain, Kara A. Christensen Pacella
wiley   +1 more source

Neonatal Abstinence Syndrome

Obstetrical & Gynecological Survey, 2016
(Abstracted from N Engl J Med 2016;375:2468–2479) Neonatal abstinence syndrome (NAS) is a postnatal opioid withdrawal syndrome occurring in 55% to 94% of newborns whose mothers were addicted to or treated with opioids while pregnant. A lack of clarity and consistency regarding the definition, measurement, and management of the syndrome still ...
Karen, McQueen, Jodie, Murphy-Oikonen
openaire   +2 more sources