Results 81 to 90 of about 84,772 (258)

Impact of cenobamate on cortical responses to transcranial magnetic stimulation in people with drug‐resistant focal epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Cenobamate (CNB) is an effective antiseizure medication, though its mechanisms of efficacy remain incompletely understood. We assessed changes in cortical responses to transcranial magnetic stimulation (TMS) following CNB treatment.
Silvano R. Gefferie, Diego Jiménez‐Jiménez, Gerhard H. Visser, Robert M. Helling, Arn M. J. M. van den Maagdenberg, Josemir W. Sander, Simona Balestrini, Roland D. Thijs   +7 more
wiley   +1 more source

A first in disease trial of the safety, tolerability, and anti‐seizure effects of ES‐481 in drug‐resistant epilepsy

Epilepsia Open, EarlyView.
Abstract Objectives ES‐481 is a novel potent and selective antagonist of TARP‐y8‐dependent AMPA receptors. We aimed to assess the potential efficacy, safety and tolerability, and pharmacokinetics of different doses of ES‐481 as an add‐on anti‐seizure medication (ASM) in adults with drug‐resistant epilepsy (DRE). Methods This was a Phase 2A double‐blind,
Emma C. Foster, Lyn Millist, Jack Germaine, Stephanie Chamorro, Caitlin Roberts, John‐Paul Nicolo, Sean Hosking, Piero Perucca, Saul Mullen, Heather Robinson, Rebecca Wharrie, Brittany Walsh, David Reutens, Kimberley Irwin, Hao Zeng, Robert Niecestro, Terence J. O'Brien   +16 more
wiley   +1 more source

Long‐Term Effectiveness of Inpatient and Day‐Hospital Treatment of Eating Disorders in Departments of Psychosomatic Medicine and Psychotherapy in Germany

European Eating Disorders Review, EarlyView.
ABSTRACT Background There is ample evidence on the efficacy of different therapeutic approaches in treating eating disorders. Yet, studies on the effectiveness of inpatient/day‐hospital treatment of eating disorders are rare. Method Data were retrieved from a naturalistic multi‐center effectiveness study of inpatient and day‐hospital treatment in ...
Magdalena Pape, Stephan Herpertz, Stephan Doering, Henrik Kessler, Martina de Zwaan, Almut Zeeck, Armin Hartmann, Tobias Hofmann, Matthias Rose, Katrin Imbierowicz, Franziska Geiser, Ilona Croy, Kerstin Weidner, Jörg Rademacher, Silke Michalek, Eva Morawa, Yesim Erim, Eva‐Maria Skoda, Martin Teufel, Stanislav Heinzmann, Claas Lahmann, Eva Milena Johanne Peters, Johannes Kruse, Dirk von Boetticher, Christoph Herrmann‐Lingen, Mariel Nöhre, Ulrike Dinger, Hans‐Christoph Friederich, Alexander Niecke, Christian Albus, Rüdiger Zwerenz, Manfred Beutel, Casper Roenneberg, Peter Henningsen, Barbara Stein, Christiane Waller, Karsten Hake, Carsten Spitzer, Andreas Stengel, Stephan Zipfel, Katja Weimer, Harald Gündel, Aram Kehyayan   +42 more
wiley   +1 more source

Design, Implement, Sustain: Advancing Program‐Led Interventions for Binge Eating, a Narrative Review

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Most individuals with binge eating never receive treatment, partly due to a lack of specialists and long waitlists. Program‐led interventions are scalable, and their therapeutic content and guidance are embedded within the program itself. However, they are not widely implemented in routine care.
Bernou Melisse, Sanne F. W. Marcic‐van Doornik, Annemarie van Elburg   +2 more
wiley   +1 more source

Kappa-opioid receptor gene (OPRK1) variations associated with opioid abstinence behaviors among chronic heroin users

Frontiers in Pharmacology
IntroductionResearch suggests kappa-opioid receptors (KORs) modulate drug use and stress-related behaviors. While some findings indicate KORs could influence initial susceptibility to opioid use disorder (OUD), few studies have examined whether ...
Mark K. Greenwald, Catherine Demery, Tabitha E. H. Moses, Margit Burmeister   +3 more
doaj   +1 more source

Sleep Health in Bulimia Nervosa: A Systematic Review

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Research on sleep in bulimia nervosa (BN) is methodologically varied and yields inconsistent findings. This review synthesised BN‐sleep studies and examined whether comorbid mood disorders contribute to sleep disturbance. Method PsycINFO, Medline (Ovid), and Scopus were searched for English or French quantitative studies comparing ...
Samantha Kenny, Malka Hershon, Linda Booij, Rebecca Burdayron, Marie‐Hélène Pennestri   +4 more
wiley   +1 more source

Patterns of Executive Function Impairment in Abstinent Individuals with Alcohol Dependence Syndrome: A Cross-sectional Study

Journal of Clinical and Diagnostic Research
Introduction: Alcohol has historically been a part of human culture, but chronic alcohol use is linked to a range of neurocognitive and psychological impairments.
Tellcott Solomon Maria Annita, Chithiravelu Sivabackiya, OT Sabari Sridhar, Sureshkumar Kailash   +3 more
doaj   +1 more source

Age, sexual abstinence duration, sperm morphology, and motility are predictors of sperm DNA fragmentation

Reproductive Medicine and Biology
Purpose Sperm DNA fragmentation (SDF) has recently received attention as a cause of male infertility. However, SDF cannot be fully assessed using conventional semen parameter evaluations alone.
Kento Yoshiakwa‐Terada, Hiroki Takeuchi, Ryota Tachibana, Erina Takayama, Eiji Kondo, Tomoaki Ikeda   +5 more
doaj   +1 more source

Providing Mental Health and Substance Use Services to People Released From Custody During the COVID‐19 Pandemic: A Qualitative Study of Service Providers

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT This paper explores the perspectives of mental health and substance use providers who supported people released from custody during the pandemic in Ontario, Canada, with a focus on service disruptions, adaptations, and experiences. We conducted 20 in‐depth qualitative interviews and analysed these using Applied Thematic Analysis.
Lucas M. Seuren, Arthur McLuhan, Madison Ford, Nikoleta Curcin, Angela Mashford‐Pringle, Patricia O'Campo, Flora I. Matheson   +6 more
wiley   +1 more source

Attentional biases in abstinent patients with cocaine use disorder: rapid orienting or delayed disengagement?

Frontiers in Psychology
Addiction-related attentional biases may play a central role in the development and maintenance of drug-seeking and drug-taking behaviors. However, evidence in cocaine dependence is limited and mixed.
Victoria Branchadell, Rosario Poy, Pilar Segarra, Pablo Ribes-Guardiola, Javier Moltó   +4 more
doaj   +1 more source