Results 271 to 280 of about 162,999 (382)

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Rapid Detection of an ABT-737-Sensitive Primed for Death State in Cells Using Microplate-Based Respirometry

, 2012
Pascaline Clerc, Gregory B. Carey, Zara Mehrabian, Michael C. Wei, Hyehyun Hwang, Geoffrey D. Girnun, Hegang Chen, Stuart S. Martin, Brian M. Polster   +8 more
openalex   +2 more sources

Decoding Senescence‐Driven Heterogeneity in Early‐Onset Colorectal Cancer for Prognostic and Therapeutic Stratification

Cancer Science, EarlyView.
We uncovered pronounced and heterogeneous tumor senescence in EOCRC, independent of age. By integrating multi‐omics and single‐cell analyses, we developed EO‐Senscore, a prognostic tool that stratifies patients by immune phenotype and therapy response, enabling precision treatment using immunotherapy or senolytic agents. ABSTRACT Early‐onset colorectal
Du Cai, Mingru Mai, Rende Huang, Haoning Qi, Xingzhi Feng, Qianling Gao, Yinmeng Zhang, Chenghang Li, Xiaojian Wu, Yize Mao, Zihuan Yang, Feng Gao   +11 more
wiley   +1 more source

Design and Factorial Optimization of Curcumin and Resveratrol Co-Loaded Lipid Nanocarriers for Topical Delivery. [PDF]

Pharmaceutics
Vaiss DP, Dias DCC, Yurgel VC, Araujo FBV, Porto LC, Burkert JFM, Marinho MAG, Filgueira DMVB, Dora CL.   +8 more
europepmc   +1 more source

IAP Antagonists Selectively Eliminate Therapy‐Induced Senescent Cancer Cells via TNFα‐Independent Apoptosis

Cancer Science, EarlyView.
Upon chemotherapy, a subset of cancer cells enters a senescent state, referred to as TIS. When IAP antagonists are administered, TIS cells are selectively eliminated through TNFα‐independent apoptosis. TNFα secreted by TIS cancer cells may also act in a paracrine manner to enhance extrinsic apoptosis in neighboring non‐senescent cancer cells.
Hiroaki Ochiiwa, Takeshi Wakasa, Yuki Kataoka, Koji Ando, Eiji Oki, Yoshihiko Maehara, Makoto Iimori, Hiroyuki Kitao   +7 more
wiley   +1 more source

<i>Trametes polyzona</i> as a Source for Bioremediation and Industrial Applications: A Systematic Review. [PDF]

J Fungi (Basel)
Ochoa-Ocampo MA, Macas-Granizo MB, Espinosa de Los Monteros-Silva N, Garzón T, Balcazar-Sinailin AJ, Niño-Ruiz Z, Torres-Gutiérrez R, Almeida JR, Mogollón NGS, Diéguez-Santana K.   +9 more
europepmc   +1 more source

Percent radical scavenging activity (%RSA) of Trolox, vetiver, lemongrass, and clove bud essential oils at various concentrations, as determined by the ABTS assay.

Acharawan Thongmee (22477769), Oraphan Wanakhachornkrai (16868221), Watchara Chongsa (22477772), Patamaporn Sukplang (22477775)   +3 more
openalex   +1 more source

On the Ambiguities of Laclauian Populist Leadership

Constellations, EarlyView.
Riku Kusumoto
wiley   +1 more source

Woollen fabric design with bioactive properties using Anatolian sweetgum tree (Liquidambar orientalis L.) leaves and fruits

Coloration Technology, EarlyView.
Abstract The recent focus among natural dyers is on identifying and utilising new natural dye sources. The current study explored the potential of the Anatolian sweetgum tree's leaves and fruits in providing bioactive properties with wool dyeing. In the dyeing process, iron (II) sulphate, alum, tannic acid and citric acid were used, and different ...
Hüseyin Benli, Emine Kılıçkaya Selvi, Ömer Aydınlıoğlu, Muhammed İbrahim Bahtiyari   +3 more
wiley   +1 more source

From sonochemical synthesis to predictive modeling: Unraveling the antioxidant properties of La-doped CeO₂ nanoparticles. [PDF]

Ultrason Sonochem
Mejía-Méndez JL, Reza-Zaldívar EE, Navarro-López DE, Sanchez-Martinez A, Ceballos-Sanchez O, Badillo M, Sánchez López AL, Yacaman MJ, Jacobo-Velázquez DA, López-Mena ER, Sanchez-Ante G.   +10 more
europepmc   +1 more source