Results 61 to 70 of about 483,708 (267)
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
California Fish and Wildlife Journal, 2022 Historically, aerial surveys have been used widely to monitor abundance of large mammals in the western United States. In California, such surveys have typically served as minimum count indices rather than true abundance estimates. Here, we evaluated the
Thomas J. Batter +3 more
doaj +1 more source
Estimating demographic parameters using a combination of known-fate and open N-mixture models
, 2015 1. Accurate estimates of demographic parameters are required to infer appropriate ecological relationships and inform management actions. Recently developed N-mixture models use count data from unmarked individuals to estimate demographic parameters, but
Adams, Layne G. +3 more
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Frontiers in Marine ScienceThe Cumberland Sound beluga whale (Delphinapterus leucas) population inhabits Cumberland Sound on the southeast side of Baffin Island, Nunavut. The population is listed as threatened under the Species at Risk Act.
Bryanna A. H. Sherbo +5 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Direct Assessment of Juvenile Atlantic Bluefin Tuna: Integrating Sonar and Aerial Results in Support of Fishery-Incident Surveys [PDF]
, 2014 There is a clear need for direct assessment approaches for Atlantic bluefin tuna (Thunnus thynnus, ABFT), including formulation of experimental designs and pilot surveys for abundance estimation.
Jech, Michael +4 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source