Results 1 to 10 of about 1,169,779 (313)

Striatal D1 and D2 receptor availability are selectively associated with eye-blink rates after methylphenidate treatment

Communications Biology, 2022
PET imaging in human participants revealed that D1 and D2 dopamine receptor availability was associated with eye-blink rates following treatment with oral methylphenidate, but not a placebo.
Şükrü B. Demiral, Peter Manza, Erin Biesecker, Corinde Wiers, Ehsan Shokri-Kojori, Katherine McPherson, Evan Dennis, Allison Johnson, Dardo Tomasi, Gene-Jack Wang, Nora D. Volkow   +10 more
doaj   +1 more source

Cortical D1 and D2 dopamine receptor availability modulate methylphenidate-induced changes in brain activity and functional connectivity

Communications Biology, 2022
Joint PET and MRI analyses of cortical D1 and D2 dopamine receptors in healthy adults provide a framework for understanding how dopamine-boosting drugs alter brain function.
Peter Manza, Ehsan Shokri-Kojori, Şükrü Barış Demiral, Corinde E. Wiers, Rui Zhang, Natasha Giddens, Katherine McPherson, Erin Biesecker, Evan Dennis, Allison Johnson, Dardo Tomasi, Gene-Jack Wang, Nora D. Volkow   +12 more
doaj   +1 more source

Prediction of stress and drug craving ninety minutes in the future with passively collected GPS data

npj Digital Medicine, 2020
Just-in-time adaptive interventions (JITAIs), typically smartphone apps, learn to deliver therapeutic content when users need it. The challenge is to “push” content at algorithmically chosen moments without making users trigger it with effortful input ...
David H. Epstein, Matthew Tyburski, William J. Kowalczyk, Albert J. Burgess-Hull, Karran A. Phillips, Brenda L. Curtis, Kenzie L. Preston   +6 more
doaj   +1 more source

Neural circuit selective for fast but not slow dopamine increases in drug reward

Nature Communications, 2023
The faster a drug enters the brain, the greater its addictive potential, yet the brain circuits underlying the rate dependency to drug reward remain unresolved.
Peter Manza, Dardo Tomasi, Ehsan Shokri-Kojori, Rui Zhang, Danielle Kroll, Dana Feldman, Katherine McPherson, Catherine Biesecker, Evan Dennis, Allison Johnson, Kai Yuan, Wen-Tung Wang, Michele-Vera Yonga, Gene-Jack Wang, Nora D. Volkow   +14 more
doaj   +1 more source

Dopamine transients do not act as model-free prediction errors during associative learning

Nature Communications, 2020
Dopamine neurons are proposed to signal the reward prediction error in model-free reinforcement learning algorithms. Here, the authors show that when given during an associative learning task, optogenetic activation of dopamine neurons causes associative,
Melissa J. Sharpe, Hannah M. Batchelor, Lauren E. Mueller, Chun Yun Chang, Etienne J. P. Maes, Yael Niv, Geoffrey Schoenbaum   +6 more
doaj   +1 more source

Prevention of child sexual abuse in the USA: a scoping review protocol of US legislative policies

BMJ Open, 2023
Introduction Child sexual abuse (CSA) poses a significant threat to the health and well-being of children in the USA and globally. Many states have introduced or implemented policies to address and prevent CSA, but little research has linked the effects ...
Melissa T Merrick, Claire E Helpingstine, Catherine A Murphy, J Bart Klika   +3 more
doaj   +1 more source

Work after mental-health-related absence: a qualitative study of perceived change after a combination of metacognitive therapy and work-focused interventions

BMC Public Health, 2022
Background Sick leave caused by common mental health disorders (CMD) is becoming more prevalent. For most people, work is essential for good mental and physical health.
Marianne Tranberg Bjørndal, Fay Giæver, Bente Marianne Aschim, Ragne Gunnarsdatter Hole Gjengedal, Hilde Dallavara Lending, Bente Bull-Hansen, Marit Hannisdal, Odin Hjemdal   +7 more
doaj   +1 more source

Identification of ER/SR resident proteins as biomarkers for ER/SR calcium depletion in skeletal muscle cells

Orphanet Journal of Rare Diseases, 2022
Background Aberrations to endoplasmic/sarcoplasmic reticulum (ER/SR) calcium concentration can result in the departure of endogenous proteins in a phenomenon termed exodosis.
Lacey K. Greer, Katherine G. Meilleur, Brandon K. Harvey, Emily S. Wires   +3 more
doaj   +1 more source

The psychological impacts of content moderation on content moderators: A qualitative study

Cyberpsychology: Journal of Psychosocial Research on Cyberpspace, 2023
Content moderation generally refers to the practice of monitoring user generated content and applying a set of rules defining what is acceptable. As a result, Content Moderators (CMs) are responsible for reviewing and removing harmful online material ...
Ruth Spence, Antonia Bifulco, Paula Bradbury, Elena Martellozzo, Jeffrey DeMarco   +4 more
doaj   +1 more source

Methylenedioxypyrovalerone (MDPV) mimics cocaine in its physiological and behavioral effects but induces distinct changes in NAc glucose

Frontiers in Neuroscience, 2015
Methylenedioxypyrovalerone (MDPV) is generally considered to be a more potent cocaine-like psychostimulant, as it shares a similar pharmacological profile with cocaine and induces similar physiological and locomotor responses.
Ken Taro Wakabayashi, Suelynn E Ren, Eugene A Kiyatkin   +2 more
doaj   +1 more source